Exploring the Link Between the Serum/Blood Levels of Heavy Metals (Pb, As, Cd, and Cu) and 2 Novel Biomarkers of Cardiovascular Stress (Growth Differentiation Factor 15 and Soluble Suppression of Tumorigenicity 2) in Copper Smelter Workers

Autor:	Basma Hussein, Mourad, Ghada Hossam, El-Sherif
Rok vydání:	2022
Předmět:	Growth Differentiation Factor 15 Public Health Environmental and Occupational Health Arsenic Lead Metals Heavy Occupational Exposure Metallurgy Humans Egypt Prospective Studies Biomarkers Copper Cadmium Environmental Monitoring
Zdroj:	Journal of Occupational & Environmental Medicine. 64:976-984
ISSN:	1536-5948 1076-2752
DOI:	10.1097/jom.0000000000002624
Popis:	Studying the association between the occupational exposure to Pb, As, Cd, and Cu with the serum levels of 2 novel biomarkers of cardiovascular stress; growth differentiation factor 15 and soluble suppression of tumorigenicity 2, in some Egyptian Cu smelter workers.Forty-one exposed workers and 41 administrative controls were clinically evaluated. Serum/blood levels of heavy metals and biomarkers were measured for both groups.The smelter workers showed significantly elevated levels of heavy metals and biomarkers compared with controls. The elevated serum levels of both biomarkers were significantly and positively correlated with each other, the levels of heavy metals, and the duration of employment of the exposed workers.There was a significant association between the levels of heavy metals and both biomarkers among the smelter workers. Further prospective studies should be performed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc9a62eaa42cff9a3fc5c0009be5f55 https://doi.org/10.1097/jom.0000000000002624 Zobrazit plný text záznamu