Histopathological findings in brain tissue obtained during epilepsy surgery
| Autor: | Blümcke, I., Spreafico, R., Haaker, G., Coras, R., Kobow, K., Bien, C.G., Pfäfflin, M., Elger, C., Widman, G., Schramm, J., Becker, A., Braun, K.P.J., Leijten, F.S.S., Baayen, J.C., Aronica, E., Chassoux, F., Hamer, H., Stefan, H., Rössler, K., Thom, M., Walker, M.C., Sisodiya, S.M., Duncan, J.S., McEvoy, A.W., Pieper, T., Holthausen, H., Kudernatsch, M., Meencke, H.J., Kahane, P., Schulze-Bonhage, A., Zentner, J., Heiland, D., Urbach, H., Steinhoff, B.J., Bast, T., Tassi, L., Lo Russo, G., Ozkara, C., Oz, B., Krsek, P., Vogelgesang, S., Runge, U., Lerche, H., Weber, Y., Honavar, M., Pimentel, J., Arzimanoglou, A., Ulate-Campos, A., Noachtar, S., Hartl, E., Schijns, O.E.M.G., Guerrini, R., Barba, C., Jacques, T.S., Cross, J.H., Feucht, M., Mühlebner, A., Grunwald, T., Trinka, E., Winkler, P.A., Gil-Nagel, A., Toledano Delgado, R., Mayer, T., Lutz, M., Zountsas, B., Garganis, K., Rosenow, F., Hermsen, A., Örtzen, T.J. von, Diepgen, T.L., Avanzini, G., Aparicio, J., Bento, C., Beckervordersandforth, J., Buccoliero, A.M., Cabral, P., Chamadoira, C., Colon, A.J., Chabardès, S., Carpenter, S., Czech, T., Dressler, A., Deleo, F., Dílio, A., Dings, J., Devaux, B., De Tisi, J., De Bellescize, J., Ebner, A., Franke, K., Groeppel, G., Giordano, F., Gozzo, F., Garbelli, R., Guenot, M., García‐Morales, I., Gómez‐Angulo, J.C., Garcia, G., Hainfellner, J.A., Höfler, J., Hoogland, G., Hendriks, M.P.H., Hofman, P., Harding, B., Huppertz, H.J., Herms, J., Hilkman, D.M.W., Hamelin, S., Idema, S., Jansen, F.E., Jahodova, A., Keeley, A., Kalss, G., Kudr, M., Kroell, J., Kokkinos, V., Keo Kosal, P., Kalbhenn, T., Leitinger, M., Landré, E., Melo Pires, M., Matas, A., Mann, M.W., Ostrowsky‐Coste, K., Prinz, M., Puttinger, G., Peraud, A., Rangel Pinho, R., Romero, C., Rego, R., Rouhl, R.P.W., Ryvlin, P., Rumia, J., Rampp, S., Scholl, T., Schulz, R., Stone, T.J., Streichenberger, N., Tisdall, M., Turak, B., Taipa, R., Uzan, M., Kranen‐Mastenbroek, V. van, Varlet, P., Vlooswijk, M.C.G., Wagner, L., Weis, S. |
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| Přispěvatelé: | Neurosurgery, Amsterdam Neuroscience - Systems & Network Neuroscience, Verpleging & Verzorging, RS: MHeNs - R3 - Neuroscience, MUMC+: MA Med Staf Spec Neurochirurgie (9), MUMC+: MA Med Staf Artsass Cardiologie (9), RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, MUMC+: HZC Med Staf Spec Klinische Neurofys (9), Beeldvorming, MUMC+: DA BV Medisch Specialisten Radiologie (9), Klinische Neurowetenschappen, MUMC+: MA Med Staf Spec Neurologie (9), MUMC+: MA Niet Med Staf Neurochirurgie (9), APH - Mental Health, APH - Aging & Later Life, Pathology, ANS - Amsterdam Neuroscience |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Pediatrics ILAE COMMISSION Disease Hippocampus Epilepsy PROPOSAL 0302 clinical medicine DIAGNOSTIC METHODS TEMPORAL-LOBE EPILEPSY Epilepsy surgery Age of Onset Child Medicine(all) Brain Neoplasms Age Factors Brain General Medicine DEPDC5 Temporal Lobe Europe Malformations of Cortical Development Databases as Topic Female TRIAL Current Literature In Clinical Science Adult TASK-FORCE REPORT medicine.medical_specialty Neuropathology CONSENSUS CLASSIFICATION Temporal lobe 03 medical and health sciences medicine Humans Hippocampal sclerosis Neuro- en revalidatiepsychologie business.industry Neuropsychology and rehabilitation psychology Plasticity and Memory [DI-BCB_DCC_Theme 3] medicine.disease TRENDS Surgery 030104 developmental biology EXPERIENCE Age of onset business 030217 neurology & neurosurgery |
| Zdroj: | New England Journal of Medicine, 377(17), 1648-1656. Massachussetts Medical Society The New England Journal of Medicine, 377, 1648-1656 Blumcke, I, Spreafico, R, Haaker, G, Coras, R, Kobow, K, Bien, C G, Pfäfflin, M, Elger, C, Widman, G, Schramm, J, Becker, A, Braun, K P, Leijten, F, Baayen, J C, Aronica, E, Chassoux, F, Hamer, H, Stefan, H, Rössler, K, Thom, M, Walker, M C, Sisodiya, S M, Duncan, J S, McEvoy, A W, Pieper, T, Holthausen, H, Kudernatsch, M, Meencke, H J, Kahane, P, Schulze-Bonhage, A, Zentner, J, Heiland, D H, Urbach, H, Steinhoff, B J, Bast, T, Tassi, L, Lo Russo, G, Özkara, C, Oz, B, Krsek, P, Vogelgesang, S, Runge, U, Lerche, H, Weber, Y, Honavar, M, Pimentel, J, Arzimanoglou, A, Ulate-Campos, A, Noachtar, S, Hartl, E & EEBB Consortium 2017, ' Histopathological findings in brain tissue obtained during epilepsy surgery ', New England Journal of Medicine, vol. 377, no. 17, pp. 1648-1656 . https://doi.org/10.1056/NEJMoa1703784 New England Journal of Medicine, 377(17), 1648-1656. MASSACHUSETTS MEDICAL SOCIETY The New England Journal of Medicine, 377, 17, pp. 1648-1656 New England Journal of Medicine, 377(17), 1648. Massachussetts Medical Society New England journal of medicine, 377(17), 1648-1656. Massachussetts Medical Society |
| ISSN: | 0028-4793 |
| DOI: | 10.1056/NEJMoa1703784 |
| Popis: | Item does not contain fulltext Background: Detailed neuropathological information on the structural brain lesions underlying seizures is valuable for understanding drug-resistant focal epilepsy. Methods: We report the diagnoses made on the basis of resected brain specimens from 9523 patients who underwent epilepsy surgery for drug-resistant seizures in 36 centers from 12 European countries over 25 years. Histopathological diagnoses were determined through examination of the specimens in local hospitals (41%) or at the German Neuropathology Reference Center for Epilepsy Surgery (59%). Results: The onset of seizures occurred before 18 years of age in 75.9% of patients overall, and 72.5% of the patients underwent surgery as adults. The mean duration of epilepsy before surgical resection was 20.1 years among adults and 5.3 years among children. The temporal lobe was involved in 71.9% of operations. There were 36 histopathological diagnoses in seven major disease categories. The most common categories were hippocampal sclerosis, found in 36.4% of the patients (88.7% of cases were in adults), tumors (mainly ganglioglioma) in 23.6%, and malformations of cortical development in 19.8% (focal cortical dysplasia was the most common type, 52.7% of cases of which were in children). No histopathological diagnosis could be established for 7.7% of the patients. Conclusions: In patients with drug-resistant focal epilepsy requiring surgery, hippocampal sclerosis was the most common histopathological diagnosis among adults, and focal cortical dysplasia was the most common diagnosis among children. Tumors were the second most common lesion in both groups. (Funded by the European Union and others.) 9 p. |
| Databáze: | OpenAIRE |
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