Seleno-polymannuronate attenuates neuroinflammation by suppressing microglial and astrocytic activation
| Autor: | Hanxing He, Hong Xu, Qingguo Han, Qiong Liu, Zhangli Hu, Jiang Yi, Qiuxian Lai, Xiaofan Li, Xu Xu, Xiuting Li, Nan Cai, Weishan Fang, Decheng Bi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Lipopolysaccharide Seleno-polymannuronate Medicine (miscellaneous) Primary astrocytes Inflammation Polysaccharide 03 medical and health sciences chemistry.chemical_compound Primary microglia 0302 clinical medicine Functional food In vivo medicine Secretion TX341-641 Neuroinflammation chemistry.chemical_classification Nutrition and Dietetics Microglia Nutrition. Foods and food supply Cell biology 030104 developmental biology medicine.anatomical_structure chemistry Anti-neuroinflammation medicine.symptom 030217 neurology & neurosurgery Food Science |
| Zdroj: | Journal of Functional Foods, Vol 51, Iss, Pp 113-120 (2018) |
| ISSN: | 1756-4646 |
| Popis: | Polymannuronate (PM) is an acidic polymer separated from alginate. PM is a linear block polysaccharide in edible brown algae that has been widely used in the food industry. Seleno-polymannuronate (Se-PM) is a seleno-derivative of PM synthesized from PM and Na2SO3 in our laboratory. We investigated the anti-neuroinflammatory activity of Se-PM in lipopolysaccharide (LPS)-activated primary microglia and astrocytes and a mouse model of acute inflammation. Our results show that Se-PM could markedly reduce NO and PGE2 production, iNOS and COX-2 expression, and TNF-α, IL-1β and IL-6 secretion in LPS-treated primary microglia and astrocytes. Moreover, the LPS-triggered overactivation of NF-κB and MAPK signalling was attenuated by Se-PM. In addition, in vivo, LPS-induced microglial and astrocytic activation was remarkably suppressed by Se-PM. These results suggest that Se-PM merits exploration as an alternative medicinal or functional food for alleviating neuroinflammation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect