Long-term olive oil-based parenteral nutrition sustains innate immune function in home patients without active underlying disease
Autor: | Peter W. M. Hermans, Geert J. A. Wanten, Hennie M.J. Roelofs, R.H.M. te Morsche, E.D. Olthof, Elles Simonetti, M.W.J. Versleijen |
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Rok vydání: | 2013 |
Předmět: |
Adult
Male Neutrophils Ascorbic Acid GPI-Linked Proteins Critical Care and Intensive Care Medicine Peripheral blood mononuclear cell Antioxidants Monocytes Selenium Antigens CD Risk Factors Humans Plant Oils Medicine L-Selectin Gamma-glutamyltransferase Molecular gastro-enterology and hepatology [IGMD 2] Olive Oil CD11b Antigen Nutrition and Dietetics Innate immune system Glutathione Disulfide biology Vitamin C business.industry Auto-immunity transplantation and immunotherapy Infection and autoimmunity [N4i 4] Pathogenesis and modulation of inflammation Infection and autoimmunity [N4i 1] Middle Aged Fish oil Ferric reducing ability of plasma Immunity Innate Soybean Oil Streptococcus pneumoniae Parenteral nutrition Integrin alpha M Immunology biology.protein Female Lipid Peroxidation Molecular gastro-enterology and hepatology Translational research [IGMD 2] Parenteral Nutrition Home business Cell Adhesion Molecules Biomarkers Granulocytes |
Zdroj: | Clinical Nutrition, 32, 4, pp. 643-9 Clinical Nutrition, 32, 643-9 |
ISSN: | 0261-5614 |
Popis: | Contains fulltext : 118743.pdf (Publisher’s version ) (Closed access) BACKGROUND & AIMS: It remains unclear whether impaired host defenses contribute to the increased risk for infectious complications seen in patients on home parenteral nutrition (HPN). The aim of this study was to compare the innate immune function of patients on olive oil-based HPN with that of healthy controls. METHODS: Innate immune functions and (anti-)oxidant balance were studied in 20 patients on olive oil-based HPN without an active underlying immune-mediated disease (Clinoleic((R)), >/=6 months; >3 times/week), and 21 age- and sex-matched healthy controls. RESULTS: Neutrophils of patients and controls had a similar capacity to eliminate Streptococcus pneumoniae. Also, levels of activation markers (CD66b, CD11b, CD62L) in granulocytes and monocytes, phorbol ester- and zymosan-induced neutrophil oxygen radical production were not different between patients and controls. No differences in (anti-)oxidant status were found, except for higher concentrations of oxidized glutathione and lower plasma selenium and vitamin C in patients compared to controls. CONCLUSION: Compromised innate immune function does not seem to explain the increased risk for infectious complications in HPN patients using olive oil-based lipid emulsions. |
Databáze: | OpenAIRE |
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