Long-term olive oil-based parenteral nutrition sustains innate immune function in home patients without active underlying disease

Autor: Peter W. M. Hermans, Geert J. A. Wanten, Hennie M.J. Roelofs, R.H.M. te Morsche, E.D. Olthof, Elles Simonetti, M.W.J. Versleijen
Rok vydání: 2013
Předmět:
Adult
Male
Neutrophils
Ascorbic Acid
GPI-Linked Proteins
Critical Care and Intensive Care Medicine
Peripheral blood mononuclear cell
Antioxidants
Monocytes
Selenium
Antigens
CD
Risk Factors
Humans
Plant Oils
Medicine
L-Selectin
Gamma-glutamyltransferase
Molecular gastro-enterology and hepatology [IGMD 2]
Olive Oil
CD11b Antigen
Nutrition and Dietetics
Innate immune system
Glutathione Disulfide
biology
Vitamin C
business.industry
Auto-immunity
transplantation and immunotherapy Infection and autoimmunity [N4i 4]
Pathogenesis and modulation of inflammation Infection and autoimmunity [N4i 1]
Middle Aged
Fish oil
Ferric reducing ability of plasma
Immunity
Innate
Soybean Oil
Streptococcus pneumoniae
Parenteral nutrition
Integrin alpha M
Immunology
biology.protein
Female
Lipid Peroxidation
Molecular gastro-enterology and hepatology Translational research [IGMD 2]
Parenteral Nutrition
Home
business
Cell Adhesion Molecules
Biomarkers
Granulocytes
Zdroj: Clinical Nutrition, 32, 4, pp. 643-9
Clinical Nutrition, 32, 643-9
ISSN: 0261-5614
Popis: Contains fulltext : 118743.pdf (Publisher’s version ) (Closed access) BACKGROUND & AIMS: It remains unclear whether impaired host defenses contribute to the increased risk for infectious complications seen in patients on home parenteral nutrition (HPN). The aim of this study was to compare the innate immune function of patients on olive oil-based HPN with that of healthy controls. METHODS: Innate immune functions and (anti-)oxidant balance were studied in 20 patients on olive oil-based HPN without an active underlying immune-mediated disease (Clinoleic((R)), >/=6 months; >3 times/week), and 21 age- and sex-matched healthy controls. RESULTS: Neutrophils of patients and controls had a similar capacity to eliminate Streptococcus pneumoniae. Also, levels of activation markers (CD66b, CD11b, CD62L) in granulocytes and monocytes, phorbol ester- and zymosan-induced neutrophil oxygen radical production were not different between patients and controls. No differences in (anti-)oxidant status were found, except for higher concentrations of oxidized glutathione and lower plasma selenium and vitamin C in patients compared to controls. CONCLUSION: Compromised innate immune function does not seem to explain the increased risk for infectious complications in HPN patients using olive oil-based lipid emulsions.
Databáze: OpenAIRE
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