Temporary changes in neutrophil-to-lymphocyte, platelet-to-lymphocyte ratios, and mean platelet volume reflecting the inflammatory process after radioiodine therapy
| Autor: | Rifki Ucler, Mahfuz Turan, Tarık Şengöz, Zekeriya Balli, Yusuf Demir, Erdem Sürücü |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Time Factors Neutrophils retrospective study Lymphocyte radioactive iodine Cell Count 030204 cardiovascular system & hematology Systemic inflammation Gastroenterology immunology Iodine Radioisotopes 0302 clinical medicine Radioiodine therapy time factor hemic and lymphatic diseases Platelet Lymphocytes Neutrophil-to-lymphocyte ratio Subclinical infection lymph node metastasis Thyroid neutrophil General Medicine female medicine.anatomical_structure 030220 oncology & carcinogenesis medicine.symptom thyroid gland tissue Adult Blood Platelets medicine.medical_specialty radiation response platelet lymphocyte ratio Mean platelet volume differentiated thyroid cancer hematological parameters Inflammation lymphocyte Article Thyroid carcinoma 03 medical and health sciences Internal medicine medicine Blood Platelets/pathology/*radiation effects Female Humans Inflammation/immunology/pathology Iodine Radioisotopes/*adverse effects/*therapeutic use Lymphocytes/cytology/*radiation effects Mean Platelet Volume Neutrophils/cytology/*radiation effects Retrospective Studies Thyroid Neoplasms/radiotherapy/surgery controlled study Radiology Nuclear Medicine and imaging human Thyroid Neoplasms outcome assessment preoperative period business.industry fungi Retrospective cohort study Platelet-to-lymphocyte ratio major clinical study postoperative care body regions thrombocyte thrombocyte volume Immunology cytology pathology business radioisotope therapy |
| Zdroj: | Nuclear Medicine Communications. 37:393-398 |
| ISSN: | 0143-3636 |
| DOI: | 10.1097/mnm.0000000000000452 |
| Popis: | Objective Data on the effects of radioiodine (RAI) therapy on systemic inflammation are very limited. The aim of this study is to explore alterations of subclinical systemic inflammatory markers, such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV), after RAI therapy in patients with differentiated thyroid carcinoma (DTC). Materials and methods We evaluated 57 DTC patients treated with RAI (RAI group), 37 DTC patients not treated with RAI (non-RAI control group), and 37 age-matched healthy individuals (healthy control group). NLR, PLR, and MPV levels were compared among the study groups; these were also examined after RAI in the RAI group. Results Initially, NLR was significantly higher in the RAI group than in the healthy controls. NLR and PLR increased significantly and MPV decreased significantly 2 months after RAI therapy (P=0.021, 0.001, and 0.008, respectively). Although NLR and PLR levels decreased, they were still high compared with the preoperative values. MPV returned to normal levels at 6 months. These parameters did not change significantly in the non-RAI control group. Conclusion This is the first study to evaluate changes in NLR, PLR, and MPV after RAI therapy. Our findings suggest that NLR, PLR, and MPV changes indicate systemic inflammation that occurs after RAI therapy because of thyroid remnant tissue ablation. Nucl Med Commun 37:393-398 © 2016 Wolters Kluwer Health, Inc. All rights reserved. |
| Databáze: | OpenAIRE |
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