Association of genetic liability to smoking initiation with e-cigarette use in young adults:A cohort study

Autor: Jasmine N. Khouja, Robyn E Wootton, George Davey Smith, Marcus R. Munafò, Amy E Taylor
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Longitudinal study
Epidemiology
Electronic Cigarettes
Social Sciences
Genome-wide association study
Electronic Nicotine Delivery Systems
Logistic regression
Adolescents
Nicotine
Cohort Studies
Habits
Families
0302 clinical medicine
Risk Factors
Smoking Habits
Medicine and Health Sciences
Medicine
Psychology
Public and Occupational Health
030212 general & internal medicine
Young adult
Children
Vaping
Smoking
General Medicine
ALSPAC
3. Good health
Nicotine Addiction
E-cigarettes
England
Perspective
psychological phenomena and processes
Cohort study
medicine.drug
Substance-Related Disorders
education
Addiction
Genetic Predisposition
03 medical and health sciences
Young Adult
Mental Health and Psychiatry
Genetic predisposition
Tobacco Smoking
Genetics
Humans
Adults
Behavior
business.industry
Biology and Life Sciences
Human Genetics
Young Adults
Polygenic risk score (PRS)
030104 developmental biology
Age Groups
Medical Risk Factors
People and Places
Genetics of Disease
Etiology
Population Groupings
business
Demography
Zdroj: Khouja, J N, Wootton, R E, Taylor, A E, Davey Smith, G & Munafo, M R 2021, ' Association of genetic liability to smoking initiation with e-cigarette use in young adults : A cohort study ', PLoS Medicine, vol. 18, no. 3, e1003555, pp. e1003555 . https://doi.org/10.1371/JOURNAL.PMED.1003555
PLoS Medicine
PLoS Medicine, Vol 18, Iss 3, p e1003555 (2021)
Popis: Background Tobacco smoking and e-cigarette use are strongly associated, but it is currently unclear whether this association is causal, or due to shared factors that influence both behaviours such as a shared genetic liability. The aim of this study was to investigate whether polygenic risk scores (PRS) for smoking initiation are associated with ever use of e-cigarettes. Methods and findings Smoking initiation PRS were calculated for young adults (N = 7,859, mean age = 24 years, 51% male) of European ancestry in the Avon Longitudinal Study of Parents and Children, a prospective birth cohort study initiated in 1991. PRS were calculated using the GWAS & Sequencing Consortium of Alcohol and Nicotine use (GSCAN) summary statistics. Five thresholds ranging from 5 × 10−8 to 0.5 were used to calculate 5 PRS for each individual. Using logistic regression, we investigated the association between smoking initiation PRS and the main outcome, self-reported e-cigarette use (n = 2,894, measured between 2016 and 2017), as well as self-reported smoking initiation and 8 negative control outcomes (socioeconomic position at birth, externalising disorders in childhood, and risk-taking in young adulthood). A total of 878 young adults (30%) had ever used e-cigarettes at 24 years, and 150 (5%) were regular e-cigarette users at 24 years. We observed positive associations of similar magnitude between smoking initiation PRS (created using the p < 5 × 10−8 threshold) and both smoking initiation (odds ratio (OR) = 1.29, 95% CI 1.19 to 1.39, p < 0.001) and ever e-cigarette use (OR = 1.24, 95% CI 1.14 to 1.34, p < 0.001) by the age of 24 years, indicating that a genetic predisposition to smoking initiation is associated with an increased risk of using e-cigarettes. At lower p-value thresholds, we observed an association between smoking initiation PRS and ever e-cigarette use among never smokers. We also found evidence of associations between smoking initiation PRS and some negative control outcomes, particularly when less stringent p-value thresholds were used to create the PRS, but also at the strictest threshold (e.g., gambling, number of sexual partners, conduct disorder at 7 years, and parental socioeconomic position at birth). However, this study is limited by the relatively small sample size and potential for collider bias. Conclusions Our results indicate that there may be a shared genetic aetiology between smoking and e-cigarette use, and also with socioeconomic position, externalising disorders in childhood, and risky behaviour more generally. This indicates that there may be a common genetic vulnerability to both smoking and e-cigarette use, which may reflect a broad risk-taking phenotype.
Databáze: OpenAIRE
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