Body mass index variations in patients with Parkinson's disease treated with levodopa-carbidopa intestinal gel infusion: A case control study versus standard of care and subthalamic nucleus deep brain stimulation
| Autor: | Christine Brefel-Courbon, K. Barange, Julia Dupouy, Fabienne Ory-Magne, P. Loubière, Olivier Rascol, Estelle Harroch, B. Fernández-Rodríguez, M.-H. Fabre-Delcros, C. Barthélémy |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Deep brain stimulation Standard of care Parkinson's disease Deep Brain Stimulation medicine.medical_treatment Gastroenterology Body Mass Index Antiparkinson Agents Levodopa 03 medical and health sciences 0302 clinical medicine Subthalamic Nucleus Weight loss Internal medicine medicine Humans In patient 030212 general & internal medicine Adverse effect Retrospective Studies business.industry Case-control study Carbidopa Parkinson Disease Standard of Care medicine.disease nervous system diseases Drug Combinations surgical procedures operative nervous system Neurology Case-Control Studies Neurology (clinical) medicine.symptom business Gels therapeutics Body mass index 030217 neurology & neurosurgery |
| Zdroj: | Revue Neurologique. 177:919-923 |
| ISSN: | 0035-3787 |
| DOI: | 10.1016/j.neurol.2020.11.017 |
| Popis: | BACKGROUND Levodopa-carbidopa intestinal gel (LCIG) is an advanced therapy for patients with Parkinson Disease (PD). Weight loss has been pointed out as an adverse event of LCIG infusion. AIMS OF THE STUDY To compare weight changes between three groups of PD patients: patients treated with LCIG, patients within the first year of subthalamic deep brain stimulation (STN-DBS) and patients treated exclusively with oral treatment during 1 year of follow up. METHODS Patients treated with LCIG were retrospectively matched by age, gender, disease duration and Hoehn and Yahr to patients undergoing STN-DBS and to patients both receiving the standard of care treatment and unwilling advanced therapies (SOC). Clinical features and weight were collected at baseline, and 12 months after introducing the treatment (LCIG and STN-DBS groups) or for one year of treatment (SOC). RESULTS Eighteen patients were included in each group. They had no differences in clinical and demographic features, except for cognitive impairment. There was a mean weight (-5.8kg ±6.8) and BMI (-2.1kg/m2±2.6) reduction in the LCIG group after 12 months, while there was a slight weight loss in the SOC (-1.4kg ±3.1) and a weight increase in the STN-DBS group (5.4kg ±4.7). Differences of weight were statistically different between, LCIG and STN-DBS (P |
| Databáze: | OpenAIRE |
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