Risk of active tuberculosis in chronic kidney disease: a systematic review and meta-analysis
| Autor: | James C. Johnston, Lorena Mota, Carole Lunny, Michael E Schachter, Khalid Al-Efraij, Victoria J. Cook |
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| Rok vydání: | 2015 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty medicine.medical_treatment Population Comorbidity urologic and male genital diseases Rate ratio Risk Assessment Internal medicine medicine Humans Tuberculosis Renal replacement therapy education education.field_of_study business.industry medicine.disease female genital diseases and pregnancy complications Infectious Diseases Meta-analysis Relative risk Kidney Failure Chronic Population study Risk assessment business Kidney disease |
| Zdroj: | The International Journal of Tuberculosis and Lung Disease. 19:1493-1499 |
| ISSN: | 1815-7920 1027-3719 |
| DOI: | 10.5588/ijtld.15.0081 |
| Popis: | BACKGROUND Although the global prevalence of chronic kidney disease (CKD) is increasing, the relationship between CKD and active TB is not well described. OBJECTIVE To conduct a systematic review to evaluate active TB risk in CKD populations. METHODS We searched Ovid Medline, EMBASE and Cochrane databases and relevant journals to identify multicentre or regional studies reporting quantitative effect estimates of an association between CKD and active TB. Risk ratios and rate ratios were used as common measures of association. Pooled estimates were generated using a random-effects model. RESULTS Of 3406 papers screened, 12 eligible studies were identified with 71,374 end-stage renal disease (ESRD) patients and 560 TB cases. Meta-analysis of adjusted rate ratio data in dialysis populations showed an increased rate of 3.62 (95%CI 1.79-7.33, P < 0.001) compared to the general population, while unadjusted risk ratio data in transplant populations showed an increased risk of 11.35 (95%CI 2.97-43.41) compared to the general population. CONCLUSION We found consistent evidence of an increased risk of active TB in ESRD compared to the general population. This relationship persisted despite variability in study population, design and renal replacement therapy (RRT) modality. Further research into the role of comorbidities, RRT modality and CKD stage is required to better understand the association between CKD and active TB. |
| Databáze: | OpenAIRE |
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