Modulation of gut substance P after whole-body irradiation
| Autor: | Jocelyne Aigueperse, Virginie Esposito, Christophe Maubert, Patrick Gourmelon, Christine Linard |
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| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Physiology Ileum Substance P Biology Radiation Dosage Ionizing radiation chemistry.chemical_compound Internal medicine medicine Animals Irradiation Intestinal Mucosa Rats Wistar Receptor EC50 Gastroenterology Dose-Response Relationship Radiation Muscle Smooth Radioimmunoassay Rats Endocrinology medicine.anatomical_structure chemistry Gamma Rays Concomitant Whole-Body Irradiation Muscle Contraction |
| Zdroj: | Digestive Diseases and Sciences. 41:2070-2077 |
| ISSN: | 1573-2568 0163-2116 |
| DOI: | 10.1007/bf02093612 |
| Popis: | Exposure to ionizing radiation induces gastrointestinal dysfunction and inflammatory reactions. The present study carried out in the rat, focuses on substance P, an inflammatory mediator implicated in the control of intestinal motility. We have investigated the effects of gamma irradiation on plasma and tissue substance P levels, ileal smooth muscle activity, and properties of specific receptors. Plasma and ileal (mucosa and muscle) substance P concentrations were measured by radioimmunoassay. At doses ranging from 1 to 8 Gy, plasma substance P levels increased in a dose-dependent manner up to four days after irradiation. Ileal mucosal concentration decreased rapidly 1 hr after a 6-Gy irradiation as compared to controls. A second class of binding sites appeared three days after 6 Gy irradiation. In addition, substance P contractile effects measured on isolated ileum showed a fourfold decrease of EC50, three days after 6 Gy irradiation. These results indicated that gamma irradiation induced an increase of plasma levels concomitant with a modification of gastro-intestinal substance P specific binding sites and contractile activity. |
| Databáze: | OpenAIRE |
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