Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG)
| Autor: | David J. Irwin, Glenda M. Halliday, Kenji Sakai, Andy King, Julia Kofler, Edward B. Lee, Stephen B. Wharton, Ellen Gelpi, Irina Alafuzoff, Victoria E. Johnson, János Bencze, Kimmo J. Hatanpaa, Eileen H. Bigio, Hitoshi Takahashi, Pawel Tacik, Isidro Ferrer, Patrick R. Hof, Melissa E. Murray, John Woulfe, Istvan Bodi, Roberta Diehl Rodriguez, Sharon X. Xie, Brittany N. Dugger, Gabor G. Kovacs, Charles L. White, Herbert Budka, Zdenek Rohan, Peter T. Nelson, Vanessa D. Smith, Jillian J. Kril, Lea T. Grinberg, John Q. Trojanowski, Giorgio Giaccone, Douglas H. Smith, Carrie Caswell, Kevin F. Bieniek, Stephen M. Gentleman, Janna H. Neltner, Johannes Attems, James W. Ironside, Ian R. A. Mackenzie, Serge Weis, Seth Love, Diane Ritchie, Masaki Takao, Jon B. Toledo, Qinwen Mao, Christian Schultz, Catriona McLean, Dennis W. Dickson, Eniko Veronika Kovari, David G. Munoz, Tibor Hortobágyi, Dietmar Rudolf Thal, Danielle Seilhean, Annemieke J. M. Rozemuller, John L. Robinson, Monika Hofer, Radoslav Matej, Charles Duyckaerts, Shelley L. Forrest, Masahito Yamada |
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| Přispěvatelé: | Pathology, Amsterdam Neuroscience - Brain Imaging, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, Amsterdam Neuroscience - Complex Trait Genetics, Amsterdam Neuroscience - Neurodegeneration |
| Předmět: |
0301 basic medicine
Male Pathology Aging NEUROPATHOLOGIC CRITERIA Astròcits Neurodegenerative GUIDELINES Alzheimer's Disease Gastroenterology Severity of Illness Index ddc:616.89 0302 clinical medicine 80 and over ARGYROPHILIC GRAIN DISEASE Neuropathology Aged 80 and over Kappa value Envelliment cerebral Malalties neurodegeneratives Tau-astrogliopathy Neurodegenerative Diseases General Medicine Frontotemporal lobar degeneration Orvostudományok DEGENERATION Middle Aged ALZHEIMERS-DISEASE Frontotemporal Dementia (FTD) Neurology Tauopathies AGREEMENT Tau phosphorylation Aging brain Female Psychology Life Sciences & Biomedicine medicine.medical_specialty NEUROFIBRILLARY PATHOLOGY Clinical Sciences Clinical Neurology tau Proteins Klinikai orvostudományok Pathology and Forensic Medicine 03 medical and health sciences Cellular and Molecular Neuroscience Malalties del sistema nerviós Envelliment Internal medicine Severity of illness medicine Acquired Cognitive Impairment Humans Digital pathology Aged Science & Technology Neurology & Neurosurgery Interrater agreement Neurosciences Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ARTAG 1103 Clinical Sciences PROGRESSIVE SUPRANUCLEAR PALSY Original Articles medicine.disease Nervous system diseases Confidence interval Clinical neurology Brain Disorders Inter-rater reliability 030104 developmental biology Astrocytes BRAINNET EUROPE CONSORTIUM Dementia Neurosciences & Neurology Neurology (clinical) Tau 1109 Neurosciences 030217 neurology & neurosurgery Kappa |
| Zdroj: | Recercat. Dipósit de la Recerca de Catalunya instname Digital.CSIC. Repositorio Institucional del CSIC ARTAG group 2017, ' Multisite assessment of aging-related tau astrogliopathy (ARTAG) ', Journal of Neuropathology and Experimental Neurology, vol. 76, no. 7, pp. 605-619 . https://doi.org/10.1093/jnen/nlx041 Dipòsit Digital de la UB Universidad de Barcelona Journal of neuropathology and experimental neurology, vol 76, iss 7 Journal of Neuropathology and Experimental Neurology, 76(7), 605-619. Lippincott Williams and Wilkins Journal of Neuropathology and Experimental Neurology, Vol. 76, No 7 (2017) pp. 605-619 Kovacs, G G, Xie, S X, Lee, E B, Robinson, J L, Caswell, C, Irwin, D J, Toledo, J B, Johnson, V E, Smith, D H, Alafuzoff, I, Attems, J, Bencze, J, Bieniek, K F, Bigio, E H, Bodi, I, Budka, H, Dickson, D W, Dugger, B N, Duyckaerts, C, Ferrer, I, Forrest, S L, Gelpi, E, Gentleman, S M, Giaccone, G, Grinberg, L T, Halliday, G M, Hatanpaa, K J, Hof, P R, Hofer, M, Hortobágyi, T, Ironside, J W, King, A, Kofler, J, Kövari, E, Kril, J J, Love, S, Mackenzie, I R, Mao, Q, Matej, R, McLean, C, Munoz, D G, Murray, M E, Neltner, J, Nelson, P T, Ritchie, D, Rodriguez, R D, Rohan, Z, Rozemuller, A, Sakai, K, Schultz, C, Seilhean, D, Smith, V, Tacik, P, Takahashi, H, Takao, M, Rudolf Thal, D, Weis, S, Wharton, S B, White, C L, Woulfe, J M, Yamada, M & Trojanowski, J Q 2017, ' Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG) ', Journal of Neuropathology and Experimental Neurology, vol. 76, no. 7, pp. 605-619 . https://doi.org/10.1093/jnen/nlx041 |
| ISSN: | 0022-3069 |
| Popis: | Aging-related tau astrogliopathy (ARTAG) is a recently introduced terminology. To facilitate the consistent identification of ARTAG and to distinguish it from astroglial tau pathologies observed in the primary frontotemporal lobar degeneration tauopathies we evaluated how consistently neuropathologists recognize (1) different astroglial tau immunoreactivities, including those of ARTAG and those associated with primary tauopathies (Study 1); (2) ARTAG types (Study 2A); and (3) ARTAG severity (Study 2B). Microphotographs and scanned sections immunostained for phosphorylated tau (AT8) were made available for download and preview. Percentage of agreement and kappa values with 95% confidence interval (CI) were calculated for each evaluation. The overall agreement for Study 1 was >60% with a kappa value of 0.55 (95% CI 0.433–0.645). Moderate agreement (>90%, kappa 0.48, 95% CI 0.457–0.900) was reached in Study 2A for the identification of ARTAG pathology for each ARTAG subtype (kappa 0.37–0.72), whereas fair agreement (kappa 0.40, 95% CI 0.341–0.445) was reached for the evaluation of ARTAG severity. The overall assessment of ARTAG showed moderate agreement (kappa 0.60, 95% CI 0.534–0.653) among raters. Our study supports the application of the current harmonized evaluation strategy for ARTAG with a slight modification of the evaluation of its severity. |
| Databáze: | OpenAIRE |
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