Effect of caffeine contained in a cup of coffee on microvascular function in healthy subjects
| Autor: | Taro Uchida, Mayuko Sakanashi, Shinichiro Ueda, Hiroaki Masuzaki, Toshihiro Matsuzaki, Matao Sakanashi, Naobumi Hamadate, Haruaki Kubota, Yusuke Ohya, Masato Tsutsui, Junko Nakasone, Katsuhiko Noguchi, Mika Kina-Tanada, Shogo Ishiuchi |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Physiology Blood Pressure Placebo Coffee Fingers chemistry.chemical_compound Young Adult Double-Blind Method Caffeine Heart rate Ingestion Medicine Humans Reactive hyperemia Pharmacology Cross-Over Studies business.industry Laser-Doppler flowmetry Microcirculation lcsh:RM1-950 Endothelial function Blood flow Placebo Effect Crossover study Healthy Volunteers Surgery Blood pressure lcsh:Therapeutics. Pharmacology chemistry Regional Blood Flow Molecular Medicine Female Endothelium Vascular business |
| Zdroj: | Journal of Pharmacological Sciences, Vol 127, Iss 2, Pp 217-222 (2015) |
| ISSN: | 1347-8613 |
| Popis: | Recent epidemiological studies have demonstrated that coffee drinking is associated with reduced mortality of cardiovascular disease. However, its precise mechanisms remain to be clarified. In this study, we examined whether single ingestion of caffeine contained in a cup of coffee improves microvascular function in healthy subjects.A double-blind, placebo-controlled, crossover study was performed in 27 healthy volunteers. A cup of either caffeinated or decaffeinated coffee was drunk by the subjects, and reactive hyperemia of finger blood flow was assessed by laser Doppler flowmetry. In an interval of more than 2 days, the same experimental protocol was repeated with another coffee in a crossover manner. Caffeinated coffee intake slightly but significantly elevated blood pressure and decreased finger blood flow as compared with decaffeinated coffee intake. There was no significant difference in heart rate between caffeinated and decaffeinated coffee intake. Importantly, caffeinated coffee intake significantly enhanced post-occlusive reactive hyperemia of finger blood flow, an index of microvascular endothelial function, compared with decaffeinated coffee intake.These results provide the first evidence that caffeine contained in a cup of coffee enhances microvascular function in healthy individuals. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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