An obesogenic diet during mouse pregnancy modifies maternal nutrient partitioning and the fetal growth trajectory
| Autor: | Marika Charalambous, Owen R. Vaughan, Maria Isabel Grijalva Haro, Shruti Ayyar, M. Constancia, Wendy N. Cooper, Abigail L. Fowden, Anne C. Ferguson-Smith, Diogo Pestana, Amanda N. Sferruzzi-Perri, Barbara Musial, Graham J. Burton |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Maternal Nutritional Physiological Phenomena Offspring Placenta Biochemistry Fetal Development Mice Pregnancy Internal medicine Genetics medicine Animals Molecular Biology Fetus biology GRB10 medicine.disease Obesity Dietary Fats Mice Inbred C57BL medicine.anatomical_structure Endocrinology Gene Expression Regulation biology.protein Animal Nutritional Physiological Phenomena Female Genomic imprinting Biotechnology |
| Zdroj: | FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 27(10) |
| ISSN: | 1530-6860 |
| Popis: | In developed societies, high-sugar and high-fat (HSHF) diets are now the norm and are increasing the rates of maternal obesity during pregnancy. In pregnant rodents, these diets lead to cardiovascular and metabolic dysfunction in their adult offspring, but the intrauterine mechanisms involved remain unknown. This study shows that, relative to standard chow, HSHF feeding throughout mouse pregnancy increases maternal adiposity (+30%, P |
| Databáze: | OpenAIRE |
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