Effect of Alprazolam and Ketamine on Seizures Induced by Two Different Convulsants
| Autor: | Herink J |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1997 |
| Předmět: |
Male
050402 sociology Aziridines lcsh:Medicine Convulsants Pharmacology Convulsions Pentylenetetrazol 03 medical and health sciences 0302 clinical medicine 0504 sociology Seizures medicine Animals Ketamine Seizure activity Rats Wistar 030203 arthritis & rheumatology Experimental Therapy Alprazolam business.industry GABAA receptor 05 social sciences lcsh:R General Medicine Rats Mechanism of action Pentylenetetrazole Rat Anticonvulsants medicine.symptom business medicine.drug |
| Zdroj: | Acta Medica, Vol 40, Iss 1, Pp 9-11 (1997) |
| ISSN: | 1805-9694 1211-4286 |
| Popis: | Effect of two anticonvulsants with different mechanism of action, i.e. alprazolam and ketamine, was tested in two types of seizure activity. The first one was induced by N-(3,5-dimethoxy-4-propoxyphenylethyl)-aziridine, the second one by pentylenetetrazol. While alprazolam alleviated both the minimal as well as major paroxysms, ketamine supressed only major seizures. These effects are discussed in terms of the both N-methyl-D-aspartate and GABA receptors involvement. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|