Effects of Surgery on Prognosis of Young Women With Operable Breast Cancer in Different Marital Statuses: A Population-Based Cohort Study
| Autor: | Junsheng Zhang, Ciqiu Yang, Yi Zhang, Fei Ji, Hongfei Gao, Xiaosheng Zhuang, Weiping Li, Weijun Pan, Bo Shen, Tingfeng Zhang, Yuanqi Chen, Kun Wang |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
medicine.medical_specialty medicine.medical_treatment survival 03 medical and health sciences Population based cohort 0302 clinical medicine Breast cancer breast cancer Epidemiology medicine Breast-conserving surgery breast reconstruction 030212 general & internal medicine RC254-282 Original Research Surgical approach business.industry Hazard ratio mastectomy Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Surgery Oncology 030220 oncology & carcinogenesis breast-conserving surgery business Breast reconstruction Mastectomy |
| Zdroj: | Frontiers in Oncology, Vol 11 (2021) Frontiers in Oncology |
| Popis: | BackgroundThe influence of surgical approaches [including mastectomy, breast-conserving therapy (BCT) and post-mastectomy breast reconstruction (PMBR) on prognosis of young women (MethodsWe used the Surveillance, Epidemiology, and End Results (SEER) database to identify young women with operable breast cancer between 2004 and 2016, who underwent mastectomy, BCT or PMBR. We assessed overall survival (OS) and breast cancer-specific survival (BCSS) using the Kaplan–Meier method and hazard ratios using multivariate Cox proportional hazard regression.ResultsCompared to mastectomy, both of BCT and PMBR conferred better OS (BCT: HR = 0.79, 95%CI: 0.69–0.90, p ConclusionBoth of BCT and PMBR had improved survival compared to mastectomy for young women with operable breast cancer. The survival benefit of BCT compared to mastectomy remained significant in unmarried patients but not in married patients. |
| Databáze: | OpenAIRE |
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