Prognostic value of squamous cell carcinoma antigen in patients with uterine cervical carcinoma
| Autor: | Nandita Ghosh, Damodar B. Balar, Sunil N. Trivedi, Neelam G. Shah, Anita Bhaduri, Jyotsna M. Bhatavdekar, Minakshi K. Shukla, Neelkamal H. Karelia |
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| Rok vydání: | 1988 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Cell Uterine Cervical Neoplasms Squamous cell carcinoma Antigen 030218 nuclear medicine & medical imaging Uterine Cervical Diseases 03 medical and health sciences 0302 clinical medicine Antigen Antigens Neoplasm Cervical carcinoma medicine Humans Stage (cooking) Serpins business.industry Large cell Infant Newborn Cancer General Medicine medicine.disease Prognosis stomatognathic diseases medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Female business |
| Zdroj: | Tumori. 74(2) |
| ISSN: | 0300-8916 |
| Popis: | Squamous cell carcinoma antigen (SCC Ag) was estimated in 30 controls, in 16 patients with benign lesions of the uterine cervix, and in 51 patients with uterine cervical carcinoma. The rate of positivity of the antigen among the cancer patients was 87% (N = 49). SCC Ag estimations were of no diagnostic value, since 37% of patients with bening lesions had elevated levels compared to controls. SCC Ag was highly correlated to histologic subtype. The highest values were obtained in keratinizing tumors, followed by large cell nonkeratinizing and small cell nonkeratinizing types. Moreover, elevation of SCC Ag was statistically significant (p < 0.001) among all the three histologic subtypes compared to controls. However, SCC Ag levels were not consistently correlated to the stage of the disease. Patients with pretherapeutic SCC Ag levels above 30 ng/ml had a faster recurrence rate and shorter survival than those who exhibited antigen values below 2.0 ng/ml. From our results, it is suggested that SCC Ag has limited use as a parameter for early diagnosis of cervical carcinoma, but it seems to reflect advancement of the disease. These findings indicate that SCC Ag elevation may prove to be a valuable marker in predicting subclinical disease. |
| Databáze: | OpenAIRE |
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