Effect of cefamandole, cefuroxime and cefoxitin on yeast fecal flora of surgical patients
| Autor: | N. Thomakos, A.N. Margioris, George Samonis, E. Marinis, Anastasios Macheras, M. Sehas, S. Kanavaki, Sofia Maraki, Theodore Liakakos |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male medicine.drug_class Cephalosporin Antibiotics Colony Count Microbial Biology Microbiology Cefoxitin Feces Drug Discovery Candida albicans medicine Humans Pharmacology (medical) Cefamandole Postoperative Period Cephamycins Antibacterial agent Aged Pharmacology Cefuroxime Candidiasis General Medicine Middle Aged biology.organism_classification Corpus albicans Cephalosporins Infectious Diseases Oncology Female Digestive System medicine.drug |
| Zdroj: | Chemotherapy. 44(5) |
| ISSN: | 0009-3157 |
| Popis: | Aim of the present study was to evaluate the effect of cefamandole, cefuroxime and cefoxitin on the level of gastrointestinal (GI) colonization by Candida albicans in humans. Twenty-eight adult patients received one of these three cephalosporins for 10 days, as treatment of infection, and were studied prospectively. Quantitative stool cultures for yeasts were performed immediately before, at the end, and 1 week after discontinuation of treatment. All three antibiotics caused an increase of the yeast concentration in the fecal flora. The increase caused by cefoxitin was the highest (2.5 log10 CFU/g of stool). Our results suggest that the cephalosporins tested cause minor increases of the colonization of the GI tract by C. albicans. |
| Databáze: | OpenAIRE |
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