Genotoxicity studies on the organophosphorus insecticide chloracetophone
| Autor: | A. Kappas, M. Markaki, M. Tzoneva, R. Vachkova, S. Lalchev |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Salmonella typhimurium Salmonella Insecticides Organophosphonates Hamster Bone Marrow Cells Toxicology medicine.disease_cause Aspergillus nidulans Lethal Dose 50 Organophosphorus Compounds Bone Marrow Cricetinae Genetics medicine Animals Humans Lymphocytes Mitosis Aspergillus biology Mutagenicity Tests Rats Inbred Strains Pesticide biology.organism_classification Molecular biology Rats medicine.anatomical_structure Micronucleus test Bone marrow Genotoxicity Mutagens |
| Zdroj: | Mutation research. 240(3) |
| ISSN: | 0027-5107 |
| Popis: | Chloracetophone (O,O-dimethyl-2,2,2-trichloro-1-(chloroacetoxy)phosphonate), a new insecticide of the organophosphorus group of pesticides, was tested for genotoxicity in a variety of systems with different genetic end-points and varying parameters. The test systems included 2 microbial systems, Salmonella and Aspergillus for point mutations and mitotic segregation, respectively, and human lymphocyte cultures and mammalian bone marrow cells (from rats and hamsters treated acutely and subacutely) for chromosomal aberrations and micronuclei. Chloracetophone was negative in Aspergillus at concentrations of 1-500 micrograms/ml, in human lymphocyte cultures at concentrations of 2.5-40 micrograms/ml, in rats at doses of 420-21 mg/kg b.w. and in hamsters at doses of 210-42 mg/kg b.w. for chromosomal aberrations. It did not cause any increase of micronuclei in human lymphocytes and rat bone marrow cells but did cause a significant increase in hamster bone marrow cells. Chloracetophone induced base-pair substitutions in strain TA100 of Salmonella with and without metabolic activation at a concentration range of 2000-6000 micrograms/plate. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|