Design of 9-beta-D-arabinofuranosyladenine (ara-A) transdermal delivery system for animal studies: regulation of drug concentration in vivo
| Autor: | Georg Imanidis, David C. Baker, Fusao Komada, William M. Shannon, Sung Wan Kim, Masaharu Miyajima, Manzer J. Durrani, Teruo Okano, William I. Higuchi |
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| Rok vydání: | 1991 |
| Předmět: |
Transdermal patch
Metabolite Skin Absorption Pharmaceutical Science Pharmacology In Vitro Techniques Administration Cutaneous Models Biological chemistry.chemical_compound Mice Pharmacokinetics In vivo medicine Animals skin and connective tissue diseases Vidarabine Transdermal Mice Hairless integumentary system business.industry food and beverages Azepines biochemical phenomena metabolism and nutrition Hairless carbohydrates (lipids) chemistry Animal studies Arabinonucleosides Chromatography Thin Layer business medicine.drug |
| Zdroj: | Journal of pharmaceutical sciences. 80(10) |
| ISSN: | 0022-3549 |
| Popis: | Transdermal delivery systems of 9-beta-D-arabinofuranosyladenine (ara-A), having controlling membranes of various permeabilities, were developed and applied to Azone-pretreated hairless mouse abdominal skin. It was confirmed that the blood concentrations of ara-A and its metabolite 9-beta-D-arabinofuranosylhypoxanthine (ara-H) in hairless mice are controlled by the permeability of the controlling membrane in the transdermal patch. Furthermore, these blood concentrations were found to closely agree with the values obtained from theoretical model calculations. Finally, but importantly, the "micropharmacokinetic" behavior of ara-A in cutaneous tissue could also be predicted. These results suggest that the transdermal patch may be employed in dermal and transdermal ara-A efficacy studies in the treatment of cutaneous herpes virus infections in hairless mice. |
| Databáze: | OpenAIRE |
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