Inherited OKT4 epitope deficiency in a Chinese rhesus macaque
| Autor: | Zheng-Fei Hu, Ren-Rong Tian, Ming-Liang Zhao, Yun Wang, Ben-Bo Liu, Yong-Tang Zheng |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Genetics
chemistry.chemical_classification education.field_of_study General Veterinary biology Transition (genetics) Population hemic and immune systems chemical and pharmacologic phenomena biology.organism_classification Phenotype Macaca mulatta Epitope Thymine Amino acid Rhesus macaque chemistry.chemical_compound Epitopes chemistry CD4 Antigens Animals Animal Science and Zoology education Cytosine |
| Zdroj: | Journal of medical primatologyREFERENCES. 50(3) |
| ISSN: | 1600-0684 |
| Popis: | OKT4 is an important epitope of the CD4 molecular. Amino acid mutations in the CD4V3 region result in deficiency of the OKT4 epitope in human. Here, we firstly reported a case of hereditary deficiency of OKT4 epitope in an inbred Chinese rhesus macaque family. This epitope deficiency is due to cytosine to thymine transition and homozygote at the nucleotide position 793 of CD4 coding sequences, which leads to the replace of arginine at 265th position of CD4 molecule by tryptophan. The results reveal that OKT4 epitope deficiency is a very old phenotype and may be parentally inherited, and emphasize the importance of avoiding inbreeding in primate population breeding. |
| Databáze: | OpenAIRE |
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