Chemokine binding proteins: An immunomodulatory strategy going viral
| Autor: | Abel Viejo-Borbolla, Kai A. Kropp, Víctor González-Motos |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
CCR1 Endocrinology Diabetes and Metabolism Immunology Biology CCL7 General Biochemistry Genetics and Molecular Biology vCKBP 03 medical and health sciences Chemokine receptor Viral Proteins Immunology and Allergy Animals Humans CCL13 Immune evasion Biochemistry Genetics and Molecular Biology(all) Herpesvirus Chemokine activity 3. Good health Cell biology CXCL2 030104 developmental biology Glycosaminoglycan Chemokine binding Chemokine Virus Diseases Poxvirus Chemokines Carrier Proteins CCL21 Protein Binding |
| Zdroj: | Cytokinegrowth factor reviews. 30 |
| ISSN: | 1879-0305 |
| Popis: | Chemokines are chemotactic cytokines whose main function is to direct cell migration. The chemokine network is highly complex and its deregulation is linked to several diseases including immunopathology, cancer and chronic pain. Chemokines also play essential roles in the antiviral immune response. Viruses have therefore developed several counter strategies to modulate chemokine activity. One of these is the expression of type I transmembrane or secreted proteins with the ability to bind chemokines and modulate their activity. These proteins, termed viral chemokine binding proteins (vCKBP), do not share sequence homology with host proteins and are immunomodulatory in vivo. In this review we describe the discovery and characterization of vCKBP, explain their role in the context of infection in vivo and discuss relevant novel findings. |
| Databáze: | OpenAIRE |
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