In vitro evaluation of cerebrospinal fluid velocity measurement in type I Chiari malformation: repeatability, reproducibility, and agreement using 2D phase contrast and 4D flow MRI
| Autor: | Eleonora Fornari, Audrey Qiuyan Fu, Gwendolyn Williams, Suraj Thyagaraj, Francesco Santini, Francis Loth, Alexander C. Bunck, John N. Oshinski, Bryn A. Martin, Mark G. Luciano, Daniel Giese |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Models
Anatomic Phase contrast microscopy Chiari malformation lcsh:RC346-429 030218 nuclear medicine & medical imaging law.invention 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Cerebrospinal fluid Magnetic resonance imaging Meta-Analysis as Topic Developmental Neuroscience law Phase contrast Humans Medicine Velocity measurement Type I Chiari malformation lcsh:Neurology. Diseases of the nervous system Reproducibility Spinal cord medicine.diagnostic_test business.industry Research Reproducibility of Results General Medicine Repeatability medicine.disease Arnold-Chiari Malformation Review Literature as Topic Neurology Child Preschool Hydrodynamics business Nuclear medicine 030217 neurology & neurosurgery |
| Zdroj: | Fluids and Barriers of the CNS, Vol 18, Iss 1, Pp 1-15 (2021) Fluids and Barriers of the CNS |
| ISSN: | 2045-8118 |
| Popis: | Background Phase contrast magnetic resonance imaging, PC MRI, is a valuable tool allowing for non-invasive quantification of CSF dynamics, but has lacked adoption in clinical practice for Chiari malformation diagnostics. To improve these diagnostic practices, a better understanding of PC MRI based measurement agreement, repeatability, and reproducibility of CSF dynamics is needed. Methods An anatomically realistic in vitro subject specific model of a Chiari malformation patient was scanned three times at five different scanning centers using 2D PC MRI and 4D Flow techniques to quantify intra-scanner repeatability, inter-scanner reproducibility, and agreement between imaging modalities. Peak systolic CSF velocities were measured at nine axial planes using 2D PC MRI, which were then compared to 4D Flow peak systolic velocity measurements extracted at those exact axial positions along the model. Results Comparison of measurement results showed good overall agreement of CSF velocity detection between 2D PC MRI and 4D Flow (p = 0.86), fair intra-scanner repeatability (confidence intervals ± 1.5 cm/s), and poor inter-scanner reproducibility. On average, 4D Flow measurements had a larger variability than 2D PC MRI measurements (standard deviations 1.83 and 1.04 cm/s, respectively). Conclusion Agreement, repeatability, and reproducibility of 2D PC MRI and 4D Flow detection of peak CSF velocities was quantified using a patient-specific in vitro model of Chiari malformation. In combination, the greatest factor leading to measurement inconsistency was determined to be a lack of reproducibility between different MRI centers. Overall, these findings may help lead to better understanding for application of 2D PC MRI and 4D Flow techniques as diagnostic tools for CSF dynamics quantification in Chiari malformation and related diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|