Immunization with avian metapneumovirus harboring chicken Fc induces higher immune responses
| Autor: | Hyun-Jin Shin, Sarita Paudel, Hyun Jang, Joo-Hun Kim, Ho-Kyoung Jung, Maheswaran Easwaran |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cancer Research animal structures Recombinant Fusion Proteins Interleukin-1beta Gene Expression Antibodies Viral Proinflammatory cytokine Interferon-gamma Viral Proteins 03 medical and health sciences Immune system Interferon Virology Chlorocebus aethiops medicine Animals Metapneumovirus Neutralizing antibody Vero Cells Poultry Diseases Paramyxoviridae Infections biology Interleukin Viral Vaccines Antibodies Neutralizing Immunoglobulin Fc Fragments 030104 developmental biology Infectious Diseases Vero cell biology.protein Immunization Antibody Chickens Plasmids medicine.drug |
| Zdroj: | Virus Research. 220:129-135 |
| ISSN: | 0168-1702 |
| DOI: | 10.1016/j.virusres.2016.04.014 |
| Popis: | In this study, we evaluated the immune responses of avian metapneumovirus harboring chicken Fc molecule. Stable Vero cells expressing chicken Fc chimera on its surface (Vero-cFc) were established, and we confirmed that aMPV grown in Vero-cFc incorporated host derived chimera Fc into the aMPV virions. Immunization of chicken with aMPV-cFc induced higher level of antibodies and inflammatory cytokines; (Interferon (IFN)-γ and Interleukin (IL)-1β) compared to those of aMPV. The increased levels of antibodies and inflammatory cytokines in chicken immunized with aMPV-cFc were statistically significantly (p |
| Databáze: | OpenAIRE |
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