The effects of tramadol and fentanyl on gastrointestinal motility in septic rats
| Autor: | Melek Sakarya, N. Zeynep Ekici, Ruşen Işik, İsmet Topçu |
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| Rok vydání: | 2006 |
| Předmět: |
Agonist
Male Meal business.industry medicine.drug_class medicine.medical_treatment Perforation (oil well) Pharmacology medicine.disease Systemic inflammation Systemic Inflammatory Response Syndrome Fentanyl Rats Sepsis Anesthesiology and Pain Medicine Medicine Animals Tramadol medicine.symptom business Gastrointestinal Motility Saline medicine.drug |
| Zdroj: | Anesthesia and analgesia. 102(3) |
| ISSN: | 1526-7598 |
| Popis: | In this study, we investigated the effects of tramadol and fentanyl on gastrointestinal transit (GIT) during acute systemic inflammation in an experimental model of cecal ligation and perforation (CLP). One-hundred-twenty male Swiss-Albino rats were divided randomly into 6 groups: Group I = sham-operated + saline; Group II = sham-operated + fentanyl; Group III = sham-operated + tramadol; Group IV = CLP + saline; Group V = CLP + fentanyl; Group VI = CLP + tramadol. Suspension of charcoal was administered as an intragastric meal to measure the GIT. GIT% (mean +/- sd) were 46.1% +/- 9.8%, 43.2% +/- 9.8%, 45.9% +/- 10.2%, 33.2% +/- 9.2%, 24.9% +/- 4.1%, and 31.8% +/- 8.4% in Groups I, II, III, IV, V, and VI, respectively. GIT% was significantly less in Group V than in Groups I, II, III, and IV (P0.05). The Group VI mean value was significantly lower than those of Groups I, II, and III (P0.05) but not different from those of Groups IV and V (P0.05). The antitransit effect of fentanyl was shown to have increased in the experimental sepsis model, but no decrease in GIT was obtained with tramadol. This was thought to be the result of an associated endogenic opioid system activation and receptor upregulation in sepsis. |
| Databáze: | OpenAIRE |
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