Allopurinol, benzbromarone and risk of coronary heart disease in gout patients: A population-based study
Autor: | Yi Ho, Ching Hung Wang, Shuo Ju Chiang, Yow Shieng Uang, Hsiu Chen Lin, Li Hsuan Wang, Masao Daimon |
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Rok vydání: | 2017 |
Předmět: |
Male
musculoskeletal diseases congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Gout Allopurinol Taiwan Coronary Disease 030204 cardiovascular system & hematology Drug Administration Schedule Gout Suppressants Coronary artery disease 03 medical and health sciences Benzbromarone chemistry.chemical_compound 0302 clinical medicine Risk Factors Internal medicine medicine Humans 030212 general & internal medicine Myocardial infarction Risk factor Dose-Response Relationship Drug business.industry Incidence Hazard ratio nutritional and metabolic diseases Middle Aged Uricosuric Agents medicine.disease Uric Acid Surgery Treatment Outcome chemistry Population Surveillance Drug Therapy Combination Female Cardiology and Cardiovascular Medicine business Kidney disease medicine.drug |
Zdroj: | International Journal of Cardiology. 233:85-90 |
ISSN: | 0167-5273 |
Popis: | Background The effect of gout on the risk of developing coronary artery disease (CAD) is uncertain. Some studies have found that gout is a risk factor for acute myocardial infarction. This study examined the changes in risk of CAD in gout patients taking allopurinol and/or benzbromarone, and analyzed the dose-response relationship of both drugs with CAD incidence. Methods The medical records of one million subjects from 2000 to 2011 were provided by the Taiwan National Health Insurance Research Database. Cox proportional hazard ratio was used to compare the risk of CAD in gout patients taking allopurinol or/and benzbromarone with those taking neither drug. Hazard ratios (HR) were adjusted for possible confounding factors, including age, gender, hypertension, hyperlipidemia, diabetes mellitus, chronic kidney disease, and relevant medications. Results Of 8047 gout patients, 1422 were treated with allopurinol (Group A), 4141 with benzbromarone (Group B), and 2484 with both drugs (Group A/B) during the follow-up period. Our results showed the incidence of CAD after adjusting for covariates for Group A, Group B, and Group A/B did not significantly differ from the comparison group. However, after adjustment for covariates in dose-response analyses, treatment with over 270 defined daily doses (DDDs) of allopurinol, and over 360 DDDs of benzbromarone, was associated with a significantly reduced risk of CAD. Conclusion We found that the use of allopurinol and benzbromarone, whether alone or in combination, had a linear dose-response relationship between the numbers of defined daily doses and the risk of CAD, especially in higher DDDs. |
Databáze: | OpenAIRE |
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