The decrease of intraflagellar transport impairs sensory perception and metabolism in ageing

Autor: Yifei Zhou, Yidong Shen, Jun Zhou, Mengjiao Song, Xiumin Yan, Yincong Zhang, Xiaona Zhang, Yumin Dai
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Aging
Sensory Receptor Cells
genetic structures
media_common.quotation_subject
Science
Longevity
General Physics and Astronomy
Sensory system
AMP-Activated Protein Kinases
Biology
Article
General Biochemistry
Genetics and Molecular Biology
Animals
Genetically Modified
03 medical and health sciences
0302 clinical medicine
Intraflagellar transport
Perception
Autophagy
Animals
Cilia
Insulin-Like Growth Factor I
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Protein kinase A
media_common
Multidisciplinary
Cilium
AMPK
Biological Transport
General Chemistry
Cell biology
Ageing
030104 developmental biology
Flagella
Cellular motility
RNA Interference
Regulatory Factor X1
sense organs
030217 neurology & neurosurgery
psychological phenomena and processes
Signal Transduction
Transcription Factors
Zdroj: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
ISSN: 2041-1723
Popis: Sensory perception and metabolic homeostasis are known to deteriorate with ageing, impairing the health of aged animals, while mechanisms underlying their deterioration remain poorly understood. The potential interplay between the declining sensory perception and the impaired metabolism during ageing is also barely explored. Here, we report that the intraflagellar transport (IFT) in the cilia of sensory neurons is impaired in the aged nematode Caenorhabditis elegans due to a daf-19/RFX-modulated decrease of IFT components. We find that the reduced IFT in sensory cilia thus impairs sensory perception with ageing. Moreover, we demonstrate that whereas the IFT-dependent decrease of sensory perception in aged worms has a mild impact on the insulin/IGF-1 signalling, it remarkably suppresses AMP-activated protein kinase (AMPK) signalling across tissues. We show that upregulating daf-19/RFX effectively enhances IFT, sensory perception, AMPK activity and autophagy, promoting metabolic homeostasis and longevity. Our study determines an ageing pathway causing IFT decay and sensory perception deterioration, which in turn disrupts metabolism and healthy ageing.
Sensory perception and metabolic homeostasis are known to deteriorate with ageing, while mechanisms underlying their deterioration remain poorly understood. Here, the authors demonstrate that decrease of intraflagellar transport in the cilia of sensory neurons impairs sensory perception and metabolism in ageing C. elegans.
Databáze: OpenAIRE
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