Outcome of children with resistant and relapsed Hodgkin's disease
| Autor: | Simon T. Meller, Judith E. Kingston, A. Barrett, JS Malpas, R Sandland, ND James, Piers N. Plowman, Ross Pinkerton, T. J. McElwain |
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| Jazyk: | angličtina |
| Rok vydání: | 1992 |
| Předmět: |
Male
Cancer Research Pediatrics medicine.medical_specialty Adolescent Salvage therapy Disease Actuarial Analysis Recurrence Antineoplastic Combined Chemotherapy Protocols medicine Humans Stage (cooking) Child Complete response Hodgkin s business.industry Remission Induction Radiotherapy Dosage medicine.disease Prognosis Hodgkin Disease Surgery Lymphoma Treatment Outcome Oncology El Niño Female business Research Article |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | During the period 1974-89, 169 children with Hodgkin's disease were treated in the Paediatric Oncology Units of the Royal Marsden and St Bartholomew's Hospitals. The overall actuarial survival for the whole group was 81% at 10 years. Thirty-five of the 169 children either did not achieve a complete remission or subsequently relapsed. The estimated actuarial survival from initial relapse or failure of primary treatment was 60% at 5 years and 45% at 10 years. Over half of the patients requiring salvage therapy had declared themselves within 2 years and only 3 relapses occurred more than 3 years from diagnosis. Very few patients remain disease free long term after failure of primary and initial salvage therapy. Patients relapsing within a year of diagnosis or not achieving a complete response to primary therapy and those with disseminated relapse had a poor response to salvage therapy. A significant subgroup of patients had prolonged survival despite multiple relapses. Neither initial histology nor stage affected survival from relapse although numbers in each subgroup were small. |
| Databáze: | OpenAIRE |
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