CUX1, A Controversial Player in Tumor Development
| Autor: | Ning Liu, Qiliang Sun, Long Wan, Xuan Wang, Yu Feng, Judong Luo, Hailong Wu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research DNA damage tumor progression Review Biology medicine.disease_cause lcsh:RC254-282 Loss of heterozygosity 03 medical and health sciences 0302 clinical medicine medicine Transcription factor CUX1 Cancer KRAS mutation medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens 030104 developmental biology Oncology Tumor progression 030220 oncology & carcinogenesis Cancer research Homeobox haploinsufficient tumor suppressor Haploinsufficiency Carcinogenesis |
| Zdroj: | Frontiers in Oncology Frontiers in Oncology, Vol 10 (2020) |
| ISSN: | 2234-943X |
| Popis: | CUX1 belongs to the homeodomain transcription factor family and is evolutionarily and functionally conserved from Drosophila to humans. In addition to the involvement in various physiological events including tissue development, cell proliferation, differentiation and migration, and DNA damage response, CUX1 has been implicated in tumorigenesis. Interestingly, CUX1 has been recently recognized as a haploinsufficient tumor suppressor, which is paradoxically overexpressed in tumor cells. While loss of heterozygosity and/or mutations of CUX1 have been frequently detected in many types of cancers, genomic amplification, and overexpression of CUX1 have also been reported in cancer tissues and are correlated with higher tumor grade and poor prognosis. Therefore, deciphering the roles of different CUX1 isoforms and in different tumor stages is required to establish a CUX1-based therapeutic strategy for cancer treatment. |
| Databáze: | OpenAIRE |
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