The correlation between tumor-associated macrophage infiltration and progression in cervical carcinoma

Autor: Yang chun Feng, Jie Lv, Zhen zhen Cheng, Fan Guo, Xiumin Ma, Wei na Kong, Le Ai, Gang Zhao
Rok vydání: 2021
Předmět:
Adult
0301 basic medicine
Oncology
medicine.medical_specialty
Stromal cell
Bioinformatics
Biophysics
Uterine Cervical Neoplasms
Tumor-associated macrophage
Microbiology
Biochemistry
Metastasis
03 medical and health sciences
0302 clinical medicine
stomatognathic system
Antigens
CD
Cell Movement
Internal medicine
Tumor-Associated Macrophages
Tumor Microenvironment
Humans
Medicine
skin and connective tissue diseases
Molecular Biology
Diagnostics & Biomarkers
Research Articles
Cancer
Cervical cancer
Tumor microenvironment
Progression
business.industry
CD68
Carcinoma
Cell Biology
Middle Aged
medicine.disease
Meta-analysis
030104 developmental biology
Tumor progression
Lymphatic Metastasis
030220 oncology & carcinogenesis
Female
Tumor-associated macrophage (TAM)
business
Clinicopathological features
CD163
hormones
hormone substitutes
and hormone antagonists
Zdroj: Bioscience Reports
ISSN: 1573-4935
0144-8463
Popis: Tumor microenvironment (TME) plays a particularly important role in the progression, invasion and metastasis of cervical carcinoma (CC). Tumor-associated macrophages (TAMs) are significant components of the tumor microenvironment in CC. However, the results of studies on the correlation between TAMs and progression in CC are still controversial. This research aimed to investigate the relationship between TAMs infiltration and progression in CC. A total of 100 patients with CC were included in the study. The correlation between TAMs and clinicopathologic features was studied. Besides, a systematic literature search was conducted from legitimate electronic databases to specifically evaluate the role of TAMs in TME of cervical carcinoma. In the meta-analysis, high stromal CD68+ TAMs density was relevant to lymph node metastasis (WMD = 11.89, 95% CI: 5.30–18.47). At the same time, CD163+ M2 TAM density was associated with lymph node metastasis (OR = 2.42, 95% CI: 1.09–5.37; WMD = 39.37, 95% CI: 28.25–50.49) and FIGO stage (WMD = -33.60, 95% CI: -45.04 to -22.16). This was further confirmed in the experimental study of 100 tissues of cervical cancer. It supported a critical role of TAMs as a prospective predictor of cervical cancer. In conclusion, CD68+ TAM and CD163+ M2 TAM infiltration in CC were associated with tumor progression. And CD163+ M2 TAM infiltration was associated with more advanced FIGO stage and lymph node metastasis in CC.
Databáze: OpenAIRE
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