Pooled Analysis of external-beam RADiotherapy parameters in phase II and phase III trials in radiochemotherapy in Anal Cancer (PARADAC)
Autor: | Eleonor Rivin del Campo, J. M. A. Northover, Laurence Collette, Melissa Christiaens, Kathryn Winter, Helen Meadows, Jaffer A. Ajani, Jean François Bosset, Marc Puyraveau, Didier Peiffert, Philippe Maingon, A. Bapsi Chakravarthy, Rob Glynne-Jones, Jean Michel Hannoun-Levi, Oscar Matzinger, Karin Haustermans, Andre Konski |
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Přispěvatelé: | Service d'oncologie-radiothérapie [CHU Tenon], CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sorbonne Université (SU), University Hospitals Leuven [Leuven], Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy] (UNICANCER/ICL), UNICANCER, Perelman School of Medicine, University of Pennsylvania [Philadelphia], MD Anderson Cancer Center [Houston], The University of Texas Health Science Center at Houston (UTHealth), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] (UNICANCER/CAL), UNICANCER-Université Côte d'Azur (UCA), Vanderbilt University Medical Center [Nashville], Vanderbilt University [Nashville], European Organisation for Research and Treatment of Cancer [Bruxelles] (EORTC), European Cancer Organisation [Bruxelles] (ECCO), Service d'Oncologie Radiothérapie [CHU Pitié Salpétrière], CHU Pitié-Salpêtrière [AP-HP] |
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Oncology Cancer Research MODULATED RADIATION-THERAPY medicine.medical_treatment LOCAL-CONTROL CHEMORADIATION 0302 clinical medicine Radiation HIGH-DOSE RADIATION Radiotherapy Dosage Chemoradiotherapy Anus Neoplasms Combined Modality Therapy 3. Good health Pooled analysis Treatment Outcome Chemoradiation 030220 oncology & carcinogenesis 5-FLUOROURACIL SQUAMOUS-CELL CARCINOMA Fluorouracil Life Sciences & Biomedicine Overall treatment time medicine.medical_specialty Mitomycin MITOMYCIN-C [SDV.CAN]Life Sciences [q-bio]/Cancer [SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine Article 03 medical and health sciences Clinical Trials Phase II as Topic TREATMENT TIME Internal medicine medicine CANAL CARCINOMA Anal cancer Humans External beam radiotherapy Progression-free survival Science & Technology business.industry Proportional hazards model [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology medicine.disease Confidence interval Radiation therapy 030104 developmental biology Clinical Trials Phase III as Topic Concomitant Neoplasm Recurrence Local FOLLOW-UP business |
Zdroj: | Eur J Cancer European Journal of Cancer European Journal of Cancer, Elsevier, 2019, 121, pp.130-143. ⟨10.1016/j.ejca.2019.08.022⟩ |
ISSN: | 1879-0852 0959-8049 |
Popis: | PURPOSE: Concomitant external-beam radiochemotherapy (5-fluorouracil-mitomycin C) has become the standard of care in anal cancer since the '90s. A pooled analysis of individual patient data from 7 major trials was performed quantifying the effect of radiation therapy (RT)-related parameters on the outcome of patients with anal cancer. MATERIALS AND METHODS: Pooling databases from combined modality trials, the impact of RT parameters (total dose, gap duration, OTT: overall treatment time) on outcome including locoregional failure (LRF), 5-year progression free survival (PFS) and toxicities were investigated. Individual patient data were received for 10/13 identified published studies conducted from 1987 to 2008 (n = 3031). A Cox regression model was used (landmark = 3 months after RT for first follow-up). RESULTS: After data inspection indicating severe heterogeneity between trials, only 1343 patients from 7/10 studies received were analysed (the most recent ones, since 1994; median follow-up = 4.1 years). A higher overall 5-year LRF rate [22.8% (95% confidence interval [CI] 22.3-27.3%)] significantly correlated with longer OTT (p = 0.03), larger tumour size (p |
Databáze: | OpenAIRE |
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