Apoptosis in Primary Hyperparathyroidism
| Autor: | Romuald Wojnicz, Łukasz Mielańczyk, Adam Piecuch, Mariusz Deska, Marek Michalski, Szczepan Tyczyński, Oliwia Segiet, Marlena Brzozowa-Zasada |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty endocrine system diseases Parathyroid Hyperplasia Apoptosis Disease Parathyroid Glands 03 medical and health sciences medicine Humans Parathyroid adenoma Hyperplasia business.industry Diagnostic marker medicine.disease Hyperparathyroidism Primary 030104 developmental biology medicine.anatomical_structure Parathyroid Neoplasms Parathyroid carcinoma Surgery Parathyroid gland business Apoptosis Regulatory Proteins Primary hyperparathyroidism Biomarkers |
| Zdroj: | Journal of investigative surgery : the official journal of the Academy of Surgical Research. 31(4) |
| ISSN: | 1521-0553 |
| Popis: | Primary hyperparathyroidism (PHPT) is defined by inappropriate elevation of parathormone, caused by parathyroid hyperplasia, also known as multi-gland disease (MGD), parathyroid adenoma (PA), or parathyroid carcinoma (PC). Although several studies have already been conducted, there is a lack of a definite diagnostic marker, which could unambiguously distinguish MGD from PA or PC. The accurate and prompt diagnosis has the key meaning for effective treatment and follow-up. This review paper presents the role of apoptosis in PHPT. The comparison of the expression of Fas, TRAIL, BCL-2 family members, p53 in MGD, PA, and PC, among others, was described. The expression of described factors varies among proliferative lesions of parathyroid gland; therefore, these could serve as additional markers to assist in the diagnosis. |
| Databáze: | OpenAIRE |
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