Piper betel Compounds Piperidine, Eugenyl Acetate, and Chlorogenic Acid Are Broad-Spectrum Anti-Vibrio Compounds that Are Also Effective on MDR Strains of the Pathogen
| Autor: | Adrian Canizalez-Roman, Erika Acosta-Smith, Debmalya Barh, Vasco Azevedo, Sandeep Tiwari, Preetam Ghosh, Nidia León-Sicairos, Héctor Flores-Villaseñor, Ranjith Kumavath |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Microbiology (medical)
medicine.drug_class Antibiotics lcsh:Medicine medicine.disease_cause Article antibiotics Microbiology 03 medical and health sciences chemistry.chemical_compound Chlorogenic acid medicine Immunology and Allergy multidrug resistances Piper betel compounds Molecular Biology Pathogen 030304 developmental biology 0303 health sciences Piper General Immunology and Microbiology biology 030306 microbiology Chemistry Chloramphenicol lcsh:R fungi Pathogenic bacteria biology.organism_classification Vibrio 3. Good health Vibrio cholera Multiple drug resistance Infectious Diseases medicine.drug |
| Zdroj: | Pathogens Volume 8 Issue 2 Pathogens, Vol 8, Iss 2, p 64 (2019) |
| ISSN: | 2076-0817 |
| Popis: | The natural population of the aquatic environment supports a diverse aquatic biota and a robust seafood industry. However, this environment also provides an appropriate niche for the growth of pathogenic bacteria that cause problems for human health. For example, species of the genus Vibrio inhabit marine and estuarine environments. This genus includes species that are pathogenic to aquaculture, invertebrates, and humans. In humans, they can cause prominent diseases like gastroenteritis, wound infections, and septicemia. The increased number of multidrug resistant (MDR) Vibrio strains has drawn the attention of the scientific community to develop new broad-spectrum antibiotics. Hence, in this paper we report the bactericidal effects of compounds derived from Piper betel plants: piperidine, chlorogenic acid, and eugenyl acetate, against various strains of Vibrio species. The different MIC90 values were approximately in a range of 2&ndash 6 mg/mL, 5&ndash 16 mg/mL, 5&ndash 20 mg/mL, and 30&ndash 80 mg/mL, for piperidine, chlorogenic acid, and eugenyl acetate, respectively. Piperidine showed the best anti-Vibrio effect against the five Vibrio species tested. Interestingly, combinations of sub-inhibitory concentrations of piperidine, chlorogenic acid, and eugenyl acetate showed inhibitory effects in the Vibrio strains. Furthermore, these compounds showed synergism or partial synergism effects against MDR strains of the Vibrio species when they were incubated with antibiotics (ampicillin and chloramphenicol). |
| Databáze: | OpenAIRE |
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