Interleukin-10 polymorphisms (rs1800871, rs1800872 and rs1800896) and periodontitis risk: A meta-analysis
| Autor: | Shu-Liang Yang, Shi-Jie Huang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Single-nucleotide polymorphism Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Aggressive periodontitis Humans Genetic Predisposition to Disease Allele Periodontitis General Dentistry business.industry 030206 dentistry Cell Biology General Medicine medicine.disease Chronic periodontitis Interleukin-10 Interleukin 10 030104 developmental biology Latin America Otorhinolaryngology Meta-analysis Biomarker (medicine) business |
| Zdroj: | Archives of oral biology. 97 |
| ISSN: | 1879-1506 |
| Popis: | Objective The objective of this meta-analysis was to assess the association between three interleukin-10 (IL-10) promoter single nucleotide polymorphisms (rs1800871, rs1800872, and rs1800896) and periodontitis risk. Methods A systematic search was conducted in PubMed, Embase, and China National Knowledge Infrastructure databases and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Results Twenty-six studies met the inclusion criteria. The pooled analysis showed that rs1800871 was associated with an increased periodontitis risk under dominant model (CT + TT vs. CC: p = 0.004, OR = 1.79, 95% CI: 1.21–2.65) in Latin American populations but not in Asian (CT + TT vs. CC: p = 0.229, OR = 0.81, 95% CI: 0.58–1.14) and Caucasian (CT + TT vs. CC: p = 0.910, OR = 1.02, 95% CI: 0.75–1.39) populations. Similarly, rs1800872 conferred an increased risk of periodontitis only in Latin American populations (CA + AA vs. CC: p = 0.012, OR = 2.32, 95% CI: 1.20–4.47; A allele vs. C allele: p = 0.001, OR = 1.61, 95% CI: 1.22–2.14). No significant association was observed between rs1800896 and periodontitis risk. Subgrouping data according to periodontitis type revealed that rs1800872 was associated with both chronic periodontitis (A allele vs. C allele: p = 0.011, OR = 1.72, 95% CI: 1.13–2.62) and aggressive periodontitis (A allele vs. C allele: p = 0.038, OR = 1.32, 95% CI: 1.02–1.72). Conclusion The studies reviewed support that the IL-10 rs1800871 and rs1800872 polymorphisms may represent a potential genetic biomarker for periodontitis risk in Latin American populations. |
| Databáze: | OpenAIRE |
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