Bacterial resistance to silver nanoparticles and how to overcome it
| Autor: | Milan Kolář, Monika Smékalová, Filip Dyčka, Renata Večeřová, Ondřej Tomanec, Marek Šebela, Robert Prucek, Libor Kvítek, Aleš Panáček, Magdaléna Röderová, Radek Zbořil |
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| Rok vydání: | 2017 |
| Předmět: |
Silver
Biomedical Engineering Metal Nanoparticles Nanoparticle Bioengineering Microbial Sensitivity Tests 02 engineering and technology Drug resistance 010402 general chemistry 01 natural sciences Silver nanoparticle Antibiotic resistance Drug Stability Drug Resistance Bacterial Escherichia coli General Materials Science Electrical and Electronic Engineering biology Chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics Antimicrobial biology.organism_classification Atomic and Molecular Physics and Optics Anti-Bacterial Agents 0104 chemical sciences Pseudomonas aeruginosa Biophysics biology.protein 0210 nano-technology Antibacterial activity Flagellin Bacteria |
| Zdroj: | Nature Nanotechnology. 13:65-71 |
| ISSN: | 1748-3395 1748-3387 |
| Popis: | Silver nanoparticles have already been successfully applied in various biomedical and antimicrobial technologies and products used in everyday life. Although bacterial resistance to antibiotics has been extensively discussed in the literature, the possible development of resistance to silver nanoparticles has not been fully explored. We report that the Gram-negative bacteria Escherichia coli 013, Pseudomonas aeruginosa CCM 3955 and E. coli CCM 3954 can develop resistance to silver nanoparticles after repeated exposure. The resistance stems from the production of the adhesive flagellum protein flagellin, which triggers the aggregation of the nanoparticles. This resistance evolves without any genetic changes; only phenotypic change is needed to reduce the nanoparticles' colloidal stability and thus eliminate their antibacterial activity. The resistance mechanism cannot be overcome by additional stabilization of silver nanoparticles using surfactants or polymers. It is, however, strongly suppressed by inhibiting flagellin production with pomegranate rind extract. |
| Databáze: | OpenAIRE |
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