Comparison of plasma copeptin and multiple biomarkers for assessing prognosis of patients with aneurysmal subarachnoid hemorrhage

Autor: Yong-Ke Zheng, Qiang Zhu, Wei Hu, Ke-Yi Wang, Quan Du, Li Jiang, Hao Wang, Zhi-Hao Che, Xiao-Qiao Dong, Wen-Hua Yu, Yong-Feng Shen, Ding-Bo Yang
Rok vydání: 2017
Předmět:
Adult
Male
medicine.medical_specialty
Subarachnoid hemorrhage
Clinical Biochemistry
Gene Expression
tau Proteins
S100 Calcium Binding Protein beta Subunit
Biochemistry
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Copeptin
Cerebral vasospasm
Neurofilament Proteins
Predictive Value of Tests
Internal medicine
Glial Fibrillary Acidic Protein
medicine
Humans
Vasospasm
Intracranial
Prospective Studies
Prospective cohort study
Aged
Receiver operating characteristic
business.industry
Glasgow Outcome Scale
Biochemistry (medical)
Glycopeptides
Case-control study
Intracranial Aneurysm
Myelin Basic Protein
030208 emergency & critical care medicine
General Medicine
Middle Aged
Subarachnoid Hemorrhage
Prognosis
medicine.disease
Surgery
Case-Control Studies
Phosphopyruvate Hydratase
Predictive value of tests
Female
business
Ubiquitin Thiolesterase
Biomarkers
030217 neurology & neurosurgery
Zdroj: Clinica Chimica Acta. 475:64-69
ISSN: 0009-8981
DOI: 10.1016/j.cca.2017.10.009
Popis: Background Increased plasma copeptin concentrations are related to poor prognosis after aneurysmal subarachnoid hemorrhage (aSAH). The aim of this study was to assess prognostic significance of plasma copeptin detection compared with glial fibrillary astrocyte protein, myelin basic protein, S100B, phosphorylated axonal neurofilament subunit H, neuron-specific enolase, tau and ubiquitin carboxyl-terminal hydrolase L1 in aSAH. Methods We detected plasma concentrations of the aforementioned biomarkers in 105 healthy controls using ELISA. Their predictive ability for symptomatic cerebral vasospasm and 6-month poor outcome (Glasgow Outcome Scale score of 1–3) were compared. Results Plasma concentrations of the preceding biomarkers were highly correlated with World Federation of Neurological Surgeons subarachnoid hemorrhage scale (WFNS) scores as well as were significantly higher in patients with symptomatic cerebral vasospasm than in those without symptomatic cerebral vasospasm and in patients with poor outcome than in those with good outcome. In terms of area under receiver operating characteristic curve, their predictive value for symptomatic cerebral vasospasm and 6-month poor outcome was in the range of WFNS scores. Plasma copeptin concentration, but not plasma concentrations of other biomarkers, statistically significantly improved the predictive performance of WFNS scores. Conclusions Copeptin in plasma might have the potential to be a useful prognostic biomarker for aSAH.
Databáze: OpenAIRE
Externí odkaz: