Bone marrow fat accumulation after 60 days of bed rest persisted 1 year after activities were resumed along with hemopoietic stimulation: the Women International Space Simulation for Exploration study
| Autor: | Martin Lecompte, Michael W C Payne, Stéphane Blanc, Burkhard Mädler, Nanthan Ramachandran, Hans K. Uhthoff, Guy Trudel, Gianni Biolo, Richard L. Hughson, Lisa Bear, Charles E. Wade |
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| Přispěvatelé: | Trudel, G, Payne, M, Mädler, B, Ramachandran, N, Lecompte, M, Wade, C, Biolo, Gianni, Blanc, S, Hughson, R, Bear, L, Uhthoff, Hk, Department of Medicine, University of Ottawa [Ottawa], Department of Clinical Morphological and Technological Sciences, University of Trieste, Département Ecologie, Physiologie et Ethologie (DEPE-IPHC), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Faculty of Applied Health Sciences, University of Waterloo [Waterloo], Canadian Institutes of Health Research Grant BRS67811 European Space Agency |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Reticulocytes
Time Factors Physiology Neutrophils medicine.medical_treatment International Cooperation MESH: Hematopoiesis bed rest MESH: Neutrophils Bed rest MESH: Magnetic Resonance Imaging Head-Down Tilt Hemoglobins Leukocyte Count MESH: Lumbar Vertebrae 0302 clinical medicine Bone Marrow magnetic resonance imaging Platelet Lymphocytes Prospective Studies Adiposity 0303 health sciences Lumbar Vertebrae medicine.diagnostic_test Leptin [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] Bone Marrow Examination medicine.anatomical_structure MESH: Hemoglobins Bone fat accumulation recovery Female MESH: Bone Marrow erythropoietin medicine.drug Adult medicine.medical_specialty leukocytes 030209 endocrinology & metabolism MESH: Bed Rest MESH: Space Flight 03 medical and health sciences MESH: Head-Down Tilt Physiology (medical) Internal medicine medicine Humans MESH: Erythropoietin MESH: Weightlessness Simulation Weightlessness Simulation 030304 developmental biology MESH: Adiposity MESH: Bone Marrow Examination MESH: Humans business.industry MESH: Time Factors MESH: Adult Space Flight MESH: Reticulocytes MESH: Prospective Studies Hematopoiesis Bone marrow examination Red blood cell MESH: International Cooperation Endocrinology Erythropoietin MESH: Leukocyte Count erythrocytes Women's Health MESH: Lymphocytes Hemoglobin Bone marrow [SDE.BE]Environmental Sciences/Biodiversity and Ecology business MESH: Women's Health MESH: Female Bed Rest |
| Zdroj: | Journal of Applied Physiology Journal of Applied Physiology, American Physiological Society, 2009, 107 (2), pp.540-548. ⟨10.1152/japplphysiol.91530.2008⟩ |
| ISSN: | 8750-7587 1522-1601 |
| DOI: | 10.1152/japplphysiol.91530.2008⟩ |
| Popis: | Immobility in bed and decreased mobility cause adaptations to most human body systems. The effect of immobility on fat accumulation in hemopoietic bone marrow has never been measured prospectively. The reversibility of marrow fat accumulation and the effects on hemopoiesis are not known. In the present study, 24 healthy women (age: 25–40 yr) underwent −6° head-down bed rest for 60 days. We used MRI to noninvasively measure the lumbar vertebral fat fraction at various time points. We also measured hemoglobin, erythropoietin, reticulocytes, leukocytes, platelet count, peripheral fat mass, leptin, cortisol, and C-reactive protein during bed rest and for 1 yr after bed rest ended. Compared with baseline, the mean (± SE) fat fraction was increased after 60 days of bed rest (+2.5 ± 1.1%, P < 0.05); the increase persisted 1 yr after the resumption of regular activities (+2.3 ± 0.8%, P < 0.05). Mean hemoglobin levels were significantly decreased 6 days after bed rest ended (−1.36 ± 0.20 g/dl, P < 0.05) but had recovered at 1 yr, with significantly lower mean circulating erythropoietin levels (−3.8 ± 1.2 mU/ml, P < 0.05). Mean numbers of neutrophils and lymphocytes remained significantly elevated at 1 yr (+617 ± 218 neutrophils/μl and +498 ± 112 lymphocytes/μl, both P < 0.05). These results constitute direct evidence that bed rest irreversibly accelerated fat accumulation in hemopoietic bone marrow. The 2.5% increase in fat fraction after 60 days of bed rest was 25-fold larger than expected from historical ambulatory controls. Sixty days of bed rest accelerated by 4 yr the normal bone marrow involution. Bed rest and marrow adiposity were associated with hemopoietic stimulation. One year after subjects returned to normal activities, hemoglobin levels were maintained, with 43% lower circulating erythropoietin levels, and leukocytes remained significantly elevated across lineages. Lack of mobility alters hemopoiesis, possibly through marrow fat accumulation, with potentially wide-ranging clinical consequences. |
| Databáze: | OpenAIRE |
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