Increased Serum Procalcitonin in Newborn Infants without Infection
| Autor: | Eberhard Henkel, Christopher Sachse, Frank Dressler |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Calcitonin
Calcitonin Gene-Related Peptide Clinical Biochemistry Prohormone Calcitonin gene-related peptide Biology Infections Procalcitonin Reference Values parasitic diseases medicine Humans In patient Protein Precursors Immunoassay Biochemistry (medical) Infant Newborn Clinical course bacterial infections and mycoses Serum samples Neonatal infection Immunology Reagent Kits Diagnostic hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Clinical Chemistry. 44:1343-1344 |
| ISSN: | 1530-8561 0009-9147 |
| DOI: | 10.1093/clinchem/44.6.1343 |
| Popis: | High serum concentrations of procalcitonin, a stable 116-amino acid precursor molecule to the proteohormone calcitonin, have been reported in patients with severe systemic bacterial or fungal, but not viral, infections (1)(2). Serum procalcitonin concentrations correlated with the severity of bacterial infection and with the clinical course of the patients (3). In healthy volunteers, serum procalcitonin is barely detectable; however, it increases consistently after endotoxin injection (4). Therefore, serum procalcitonin is regarded by many authors as a useful marker of the presence, course, and prognosis of bacterial infection. To date we are aware of three reports describing the value of procalcitonin for diagnosis of neonatal infection (1)(5)(6). The reports agree that patients with bacterial invasion have high concentrations of serum procalcitonin. However, there are some discrepancies regarding the procalcitonin concentrations in sera of newborn infants without bacterial infection. In our study, procalcitonin concentrations were examined in 122 serum samples of … |
| Databáze: | OpenAIRE |
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