Acute Toxicity and Mutagenicity Study on Branched Corn Syrup and Evaluation of Its Laxative Effect in Humans
| Autor: | Shigeru Wakabayashi, Kazuhiro Ohkuma, Isao Matsuda, Hiroaki Fudaba, Yuka Kishimoto |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Diarrhea
Dietary Fiber Male Salmonella typhimurium medicine.medical_specialty food.ingredient medicine.medical_treatment Laxative Administration Oral Medicine (miscellaneous) Zea mays Median lethal dose Lethal Dose 50 Rats Sprague-Dawley Sex Factors food Animal science Oral administration Dextrins Escherichia coli Toxicity Tests Acute medicine Animals Humans Nutrition and Dietetics Dose-Response Relationship Drug Cathartics Mutagenicity Tests Chemistry Hydrolysis Lethal dose Acute toxicity Rats Surgery Corn syrup Treatment Outcome Toxicity Female medicine.symptom Mutagens |
| Zdroj: | Journal of Nutritional Science and Vitaminology. 47:126-131 |
| ISSN: | 1881-7742 0301-4800 |
| DOI: | 10.3177/jnsv.47.126 |
| Popis: | We developed a branched corn syrup (BCS, average molecular weight: 500, content of indigestible portion: 45%) by heat treatment of indigestible dextrin with hydrochloric acid. To confirm the safety of BCS, we conducted both an acute toxicity test and a mutagenicity test. Moreover, we observed gastroenteric effects of BCS in fifty healthy humans. The results are summarized as follows. 1) There was no death observed after oral administration of BCS in Sprague-Dawley-strain rats. Lethal dose (LD)50, value was estimated to be more than 10 g/kg body weight. 2) No mutagenicity was observed in Salmonella typhimurium TA98, TA100, TA1535, TA1537, or Escherichia coli WP2uvrA. 3) Fifty adults were divided into five groups often (five of each sex) and orally administered BCS at 0.2, 0.3, 0.4. 0.5 and 0.6 g/kg body weight as indigestible portion. Although no diarrhea was observed in females, BCS at 0.6 g/kg as indigestible portion caused diarrhea in two out of five males. The maximum non-effective dose of indigestible portion of BCS was estimated to be 0.5 g/kg in males and more than 0.6 g/kg in females. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|