Encapsulation of Gold-Based Anticancer Agents in Protease-Degradable Peptide Nanofilaments Enhances Their Potency

Autor:	Yaron Marciano, Virginia del Solar, Nazia Nayeem, Dhwanit Dave, Jiye Son, María Contel, Rein V. Ulijn
Rok vydání:	2022
Předmět:	Colloid and Surface Chemistry General Chemistry Biochemistry Catalysis
Zdroj:	Journal of the American Chemical Society.
ISSN:	1520-5126
Popis:	We investigated the use of amphiphilic, protease-cleavable peptides as encapsulation moieties for hydrophobic metallodrugs, in order to enhance their bioavailability and consequent activity. Two hydrophobic, gold-containing anticancer agents varying in aromatic ligand distribution (Au(I)-N-heterocyclic carbene compounds
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf9f37e8fbd10c6580bfaa071c5fd63a https://pubmed.ncbi.nlm.nih.gov/36542079 Zobrazit plný text záznamu