The activity of adenosine deaminase and oxidative stress biomarkers in scraping samples of acne lesions
| Autor: | Kurutas B Ergul, Atalay Filiz, Dokur Neslihan, Ozturk Perihan |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Antioxidant Adolescent Adenosine Deaminase medicine.medical_treatment Dermatology medicine.disease_cause Gastroenterology Severity of Illness Index Statistics Nonparametric Superoxide dismutase chemistry.chemical_compound Young Adult Adenosine deaminase Internal medicine Malondialdehyde Acne Vulgaris medicine Humans Acne Analysis of Variance biology Superoxide Dismutase Glutathione medicine.disease Catalase Oxidative Stress chemistry Case-Control Studies Immunology biology.protein Female Oxidative stress Biomarkers |
| Zdroj: | Journal of cosmetic dermatology. 11(4) |
| ISSN: | 1473-2165 |
| Popis: | SummaryBackground Acne vulgaris is one of the most common dermatological diseases, and its pathogenesis is multifactorial. Although there are some reports about role of oxidative stress biomarkers in blood, serum, plasma in the pathogenesis of acne, there has been no report about oxidative stress biomarkers in scraping samples. For this reason, the aim of our study is to determine the role of oxidative stress biomarkers and adenosine deaminase (ADA) in scraping samples of acne lesion and to determine a possible link with the clinical severity. Fifty patients with different severity of acne vulgaris and forty healthy controls were enrolled. In both groups, ADA and oxidative stress biomarkers such as the levels of malondialdehyde (MDA), and reduced glutathione (GSH), the activities of superoxide dismutase (SOD) and catalase (CAT) in scraping samples were measured spectrophotometrically. The levels of SOD, CAT, GSH, MDA, and ADA of patients with acne were higher than the control patients (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|