The moderating effect of cortisol and dehydroepiandrosterone on the relation between sleep and depression or burnout
| Autor: | Nicole Rothe, Kristin Schmelzer, Marlene Penz, Magdalena K. Wekenborg, Sabrina Vogel, Clemens Kirschbaum, Andreas Walther, Wei Gao |
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| Přispěvatelé: | University of Zurich, Walther, Andreas |
| Rok vydání: | 2021 |
| Předmět: |
Embryology
Depressive disorders health care facilities manpower and services education Dehydroepiandrosterone Neurosciences. Biological psychiatry. Neuropsychiatry Burnout Cortisol 2738 Psychiatry and Mental Health health services administration Medicine Psychology Pharmacology (medical) DHEA Depression (differential diagnoses) 2403 Immunology business.industry 10093 Institute of Psychology Cell Biology Sleep disorders Sleep quality Moderation medicine.disease Sleep in non-human animals BF1-990 Poor sleep 2712 Endocrinology Diabetes and Metabolism 2807 Endocrine and Autonomic Systems 2728 Neurology (clinical) 3201 Psychology (miscellaneous) Major depressive disorder Anatomy business 150 Psychology 2803 Biological Psychiatry psychological phenomena and processes Developmental Biology Clinical psychology Hormone RC321-571 |
| Zdroj: | Comprehensive Psychoneuroendocrinology, Vol 7, Iss, Pp 100051-(2021) |
| ISSN: | 2666-4976 |
| Popis: | For poor sleep quality (SQ) as well as major depressive disorder (MDD) and burnout, a dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis has been identified. Although poor SQ is often reported as an early symptom of MDD or burnout, it is not clear whether HPA axis-related hormones can influence the association between SQ and MDD or burnout. This manuscript addresses this question by examining HPA axis-related hormones as potential moderators influencing the association between SQ and MDD or burnout. In the fourth annual examination wave of the Dresden Burnout Study, we measured general SQ (including sleep duration and efficiency), depressive and burnout symptoms, and obtained hair samples for quantification of long-term integrated steroid concentrations (cortisol [hC], cortisone [hCn], dehydroepiandrosterone [hDHEA]) from 462 participants (67 % female). Data on SQ, depressive and burnout symptoms were available from 342 participants from the preceding examination wave (average time span between examinations 13.2 months). Cross-sectional analyses showed that the negative association between sleep duration and depressive symptoms was buffered by higher levels of hC, and hCn, whereas the negative association between sleep duration and burnout symptoms was buffered by higher levels of hDHEA. The negative association between sleep efficiency and burnout symptoms was intensified by higher levels of hC and hC/hCn ratio and the negative association between general SQ and burnout symptoms was intensified by higher levels of hC/hCn ratio. Longitudinal analyses revealed an intensifying effect of a higher hC/hCn ratio for the negative association between sleep duration and burnout symptoms. Our results suggest opposed moderation effects of hair glucocorticoids on the association between SQ and depressive or burnout symptoms. This points toward opposed glucocorticoid receptor functioning in depression and burnout. To fully elucidate the negative consequences of poor SQ on MDD and burnout, the complex underlying mechanisms of action including HPA axis-related hormones need to be investigated in MDD and burnout separately. |
| Databáze: | OpenAIRE |
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