Thymic epithelial tumors express vascular endothelial growth factors and their receptors as potential targets of antiangiogenic therapy: A tissue micro array-based multicenter study
| Autor: | Lattanzio, R, La Sorda, R, Facciolo, F, Sioletic, S, Lauriola, L, Martucci, R, Gallo, E, Palmieri, G, Evoli, A, Alessandrini, G, Ruco, L, Rendina, Ea, Truini, M, Chiarle, Roberto, Barreca, A, Pich, Achille, Ascani, S, Remotti, D, Tunesi, G, Granone, P, Ratto, Gb, Puma, F, Pescarmona, E, Piantelli, M, Marino, M, Carlini, S, Cerasoli, V, Corzani, F, Melis, E, Filippetti, M, Canalini, P, Palestro, G, Lalle, M, Ruffini, Enrico, Ceribelli, A, Rinaldi, Mauro, Thymic Epithelial Tumor Working Group |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A Cancer Research Pathology Angiogenesis Angiogenesis Inhibitors Receptor tyrosine kinase ANGIOGENESIS chemistry.chemical_compound 0302 clinical medicine Thymoma Thymic epithelial tumors Biomarkers Tissue Micro Array Vascular endothelial growth factor Vascular endothelial growth factor receptor Medicine Molecular Targeted Therapy Neoplasms Glandular and Epithelial Child Aged 80 and over 0303 health sciences HISTOLOGIC CLASSIFICATION MALIGNANT THYMOMA BREAST-CANCER CARCINOMAS VEGF INHIBITOR OVEREXPRESSION TOMOGRAPHY CHALLENGES biology Neovascularization Pathologic tissue micro array thymic epithelial tumors vascular endothelial growth factor biomarkers thymoma vascular endothelial growth factor receptor Middle Aged Immunohistochemistry 3. Good health Vascular endothelial growth factor A Oncology Vascular endothelial growth factor C 030220 oncology & carcinogenesis Female Pulmonary and Respiratory Medicine Adult medicine.medical_specialty Adolescent Antineoplastic Agents 03 medical and health sciences Paracrine signalling Young Adult Humans Autocrine signalling 030304 developmental biology Aged Neoplasm Staging Retrospective Studies Settore MED/06 - ONCOLOGIA MEDICA business.industry Thymus Neoplasms Receptors Vascular Endothelial Growth Factor chemistry Cancer cell Cancer research biology.protein business |
| Zdroj: | Lung Cancer |
| Popis: | Objectives Tumor angiogenesis is an essential and complex process necessary for the growth of all tumors which represents a potential therapeutic target. Angiogenesis inhibitors targeting vascular endothelial growth factor (VEGF) or their receptor tyrosine kinases have been approved by the FDA. In thymic epithelial tumors (TET), targeted therapies have been sporadically applied due to their rarity. To ascertain the presence of potential therapeutic targets, we analyzed by immunohistochemistry the expression of angiogenesis-related biomarkers in a large series of TET arranged in Tissue Micro Arrays (TMA). Materials and methods We assessed by immunohistochemistry the expression of the possible molecular target of anti-angiogenic therapy, i.e. VEGFA, VEGFC, VEGFD, VEGFR1, VEGFR2, VEGFR3, and PDGFRβ, in a TMA series of 200 TET collected in the framework of a multi-institutional collaborative project for Rare Diseases. Results When compared to the low-risk tumors, high-risk TET (B2, B3, carcinomas) contained higher proportion of cancer cells expressing VEGFA, VEGFC and VEGFD ( P P P P =0.002), VEGFR2 ( P =0.013), and VEGFR3 ( P =0.041). No differences were observed in terms of PDGFRβ expression. Conclusions According to our data, it is possible to hypothesize the existence of multiple paracrine and/or autocrine loops in TET, particularly in the high-risk ones, involved in TET growth and progression. Anti-angiogenic agents, directed to inhibit these loops, are therefore to be considered as potential tools in advanced TET therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|