Developing HDAC4-Selective Protein Degraders To Investigate the Role of HDAC4 in Huntington's Disease Pathology

Autor:	Natsuko Macabuag, William Esmieu, Perla Breccia, Rebecca Jarvis, Wesley Blackaby, Ovadia Lazari, Liudvikas Urbonas, Maria Eznarriaga, Rachel Williams, Annelieke Strijbosch, Rhea Van de Bospoort, Kim Matthews, Cole Clissold, Tammy Ladduwahetty, Huw Vater, Patrick Heaphy, Douglas G. Stafford, Hong-Jun Wang, John E. Mangette, George McAllister, Vahri Beaumont, Thomas F. Vogt, Hilary A. Wilkinson, Elizabeth M. Doherty, Celia Dominguez
Rok vydání:	2023
Předmět:	Neurons Disease Models Animal Huntingtin Protein Mice Huntington Disease Drug Development Drug Discovery Proteolysis Molecular Medicine Animals Ubiquitins Histone Deacetylases
Zdroj:	Journal of medicinal chemistry. 65(18)
ISSN:	1520-4804
Popis:	Huntington's disease (HD) is a lethal autosomal dominant neurodegenerative disorder resulting from a CAG repeat expansion in the huntingtin (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf9b7293f23145d9276a05495bc08822 https://pubmed.ncbi.nlm.nih.gov/36098485 Zobrazit plný text záznamu