Gastroretentive raft liquid delivery system as a new approach to release extension for carrier-mediated drug

Autor:	Ahmed A. Aboelwafa, Omaima N. El-Gazayerly, Samar M. Abouelatta
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Drug Male Cyclohexanecarboxylic Acids media_common.quotation_subject Chemistry Pharmaceutical Cmax Pharmaceutical Science Administration Oral Biological Availability 02 engineering and technology Pharmacology 030226 pharmacology & pharmacy Excipients 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Drug Delivery Systems In vivo Animals LM-pectin 101 Amines gamma-Aminobutyric Acid media_common Drug Carriers Chemistry GMO lcsh:RM1-950 Polysaccharides Bacterial raft forming systems General Medicine Factorial experiment 021001 nanoscience & nanotechnology Gellan gum Bioavailability Rats lcsh:Therapeutics. Pharmacology Gastric Mucosa Delayed-Action Preparations Drug delivery Pectins Gabapentin 0210 nano-technology Drug carrier Gels Research Article gellan gum Half-Life
Zdroj:	Drug Delivery Drug Delivery, Vol 25, Iss 1, Pp 1161-1174 (2018)
ISSN:	1521-0464 1071-7544
Popis:	Gabapentin (GBP), an antiepileptic and anti-neuropathic agent, suffers from short half-life (5–7 h), has narrow absorption window, and is absorbed via carrier-mediated mechanism resulting in frequent dosing, poor compliance, and poor bioavailability (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf9a12dd0aa10e12a295a9dcd416a301 http://europepmc.org/articles/PMC6058684 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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