Insulin-like growth factor I and its binding protein-3 are regulators of lactation and maternal responsiveness
Autor: | Árpád Dobolyi, Alán Alpár, Éva R. Szabó, Melinda Cservenák, András H. Lékó, János Hanics |
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Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
medicine.medical_specialty Science medicine.medical_treatment Biology Article 03 medical and health sciences Insulin-like growth factor 0302 clinical medicine Arcuate nucleus Internal medicine Lactation medicine Animals Insulin-Like Growth Factor I Rats Wistar Maternal Behavior Multidisciplinary Tyrosine hydroxylase Dopaminergic Prolactin Rats Insulin-Like Growth Factor Binding Protein 3 030104 developmental biology Endocrinology medicine.anatomical_structure Animals Newborn Medicine Female 030217 neurology & neurosurgery Postpartum period Hormone |
Zdroj: | Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017) Scientific Reports |
ISSN: | 2045-2322 |
Popis: | Adaptation to motherhood includes maternal behaviour and lactation during the postpartum period. The major organizing centres of maternal behaviour and lactation are located in the hypothalamic medial preoptic area (MPOA) and the arcuate nucleus, respectively. Insulin-like growth factor I (IGF-I) is an effector of the growth hormone axis; however, its function in the brain is largely unexplored. We identified increased maternal IGF binding protein-3 (IGFBP-3) expression in preoptic rat microarray data and confirmed it by RT-PCR. In situ hybridization histochemistry showed markedly elevated IGFBP-3 expression in the MPOA and the arcuate nucleus in rat dams. Prolonged intracerebroventricular injection of IGF-I or antagonism of brain IGFBP-3 with an inhibitor (NBI-31772) using osmotic minipumps increased pup retrieval time, suggesting reduced maternal motivation. Suckling-induced prolactin release and pup weight gain were also suppressed by IGF-I, suggesting reduced lactation. In addition, IGF-I-induced tyrosine hydroxylase expression and its specific phosphorylation in tuberoinfundibular dopaminergic neurons suppress prolactin secretion. Thus, IGF-I may inhibit both behavioural and lactational alterations in mothers. Neurons in the MPOA and arcuate nuclei express IGFBP-3 during the postpartum period to neutralize IGF-I effects. IGFBP-3 can prevent the blockade of maternal behaviour and lactation exerted by IGF-I, suggesting a novel modulatory mechanism underlying the behavioural and hormonal effects during central maternal adaptations. |
Databáze: | OpenAIRE |
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