Crystal Structure of the Apo and the ADP-Bound Form of Choline Kinase from Plasmodium falciparum
| Autor: | Emilio Parisini, Archimede Torretta, Luisa Carlota Lopez-Cara |
|---|---|
| Přispěvatelé: | Archimede Torretta, Luisa Carlota Lopez-Cara, Emilio Parisini |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
ADP crystal structure Choline kinase General Chemical Engineering 030106 microbiology Plasmodium falciparum malaria Inorganic Chemistry 03 medical and health sciences chemistry.chemical_compound Biosynthesis Phosphatidylcholine parasitic diseases medicine lcsh:QD901-999 Parasite hosting General Materials Science biology choline kinase Condensed Matter Physics medicine.disease biology.organism_classification Membrane synthesis 030104 developmental biology chemistry Biochemistry Drug development lcsh:Crystallography Malaria |
| Zdroj: | Crystals, Vol 10, Iss 613, p 613 (2020) Crystals Volume 10 Issue 7 |
| ISSN: | 2073-4352 |
| Popis: | Among the malaria-causing parasites, the deadliest is Plasmodium falciparum, which accounts for the majority of the fatalities. As the infection progresses inside erythrocytes, major cellular and metabolic changes take place. For its own growth, the parasite relies on the accumulation of phospholipids, which are essential for membrane synthesis. Within the Kennedy pathway, the P. falciparum choline kinase (PfChoK) has a central role in the biosynthesis of phosphatidylcholine and its selective inhibition leads to the parasite arrest and eradication. Here, we report the crystal structure of the apo and the ADP-bound form of choline kinase from Plasmodium falciparum at 2.0 and 2.2 Å resolution, respectively. These new structural data will facilitate the implementation of effective structure-based drug development strategies against PfChoK in the fight against malaria. |
| Databáze: | OpenAIRE |
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