External validation and updating of prediction models for estimating the 1-year risk of low health-related quality of life in colorectal cancer survivors

Autor: Dóra Révész, Sander M.J. van Kuijk, Floortje Mols, Fränzel J.B. van Duijnhoven, Renate M. Winkels, IJmert Kant, Piet A. van den Brandt, Luc J. Smits, Stéphanie O. Breukink, Ellen Kampman, Sandra Beijer, Matty P. Weijenberg, Martijn J.L. Bours
Přispěvatelé: Epidemiologie, RS: GROW - R1 - Prevention, MUMC+: KIO Kemta (9), RS: CAPHRI - R2 - Creating Value-Based Health Care, RS: CAPHRI - R3 - Functioning, Participating and Rehabilitation, RS: CAPHRI - R5 - Optimising Patient Care, Surgery, MUMC+: MA Heelkunde (9), RS: NUTRIM - R2 - Liver and digestive health, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Medical and Clinical Psychology
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Clinical Epidemiology, 152, 127-139. Elsevier Science
Journal of Clinical Epidemiology 152 (2022)
Journal of Clinical Epidemiology, 152, 127-139. Elsevier USA
Journal of Clinical Epidemiology, 152, 127-139
ISSN: 0895-4356
Popis: ObjectivesTimely identification of colorectal cancer (CRC) survivors at risk of experiencing low health-related quality of life (HRQoL) in the near future is important for enabling appropriately tailored preventive actions. We previously developed and internally validated risk prediction models to estimate the 1-year risk of low HRQoL in long-term CRC survivors. In this article, we aim to externally validate and update these models in a population of short-term CRC survivors.Study Design and SettingIn a pooled cohort of 1,596 CRC survivors, seven HRQoL domains (global QoL, cognitive/emotional/physical/role/social functioning, and fatigue) were measured prospectively at approximately 5 months postdiagnosis (baseline for prediction) and approximately 1 year later by a validated patient-reported outcome measure (European Organization for Research and Treatment of Cancer Quality of life Questionnaire–Core 30). For each HRQoL domain, 1-year scores were dichotomized into low vs. normal/high HRQoL. Performance of the previously developed multivariable logistic prediction models was evaluated (calibration and discrimination). Models were updated to create a more parsimonious predictor set for all HRQoL domains.ResultsUpdated models showed good calibration and discrimination (AUC ≥0.75), containing a single set of 15 predictors, including nonmodifiable (age, sex, education, time since diagnosis, chemotherapy, radiotherapy, stoma, and comorbidities) and modifiable predictors (body mass index, physical activity, smoking, anxiety/depression, and baseline fatigue and HRQoL domain scores).ConclusionExternally validated and updated prediction models performed well for estimating the 1-year risk of low HRQoL in CRC survivors within 6 months postdiagnosis. The impact of implementing the models in oncology practice to improve HRQoL outcomes in CRC survivors needs to be evaluated.
Databáze: OpenAIRE
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