No increase in anti‐A isohemagglutinin titer after SARS‐CoV ‐2 infection: A retrospective cohort analysis of group O apheresis platelet donors
| Autor: | Agnieszka Zebrowska, Magdalena Bujno, Barbara Boczkowska-Radziwon, Anna Rogowska, Piotr Radziwon, Jaroslaw Piszcz, Tomasz Wasiluk, Lukasz Bolkun, Kamila Rybinska |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Population Blood Donors Platelet Transfusion Antibodies Viral Asymptomatic SARS‐CoV‐2 Isohemagglutinin ABO Blood-Group System isohemagglutinin Cohort Studies Young Adult COVID‐19 ABO blood group system medicine Humans education Retrospective Studies transfusion platelet education.field_of_study SARS-CoV-2 business.industry Brief Report Plateletpheresis Antibody titer COVID-19 Transfusion Reaction Retrospective cohort study Hematology General Medicine Middle Aged Titer Hemagglutinins Apheresis Immunoglobulin M Immunology Female medicine.symptom business |
| Zdroj: | Journal of Clinical Apheresis |
| ISSN: | 1098-1101 0733-2459 |
| DOI: | 10.1002/jca.21942 |
| Popis: | The risk of a hemolytic reaction during the transfusion of ABO non‐identical PC is determined by the presence of natural anti‐A IgM antibodies, the titer of which may increase after infections. The aim of the study was to evaluate the titer of anti‐A isohemagglutinins in platelet concentrate (PC) obtained by apheresis from group O donors who experienced SARS‐CoV‐2 infection, and to compare the titer before and after infection. A retrospective single‐center analysis of 21 PC donors with a previous COVID‐19 history was performed. The results showed neither a statistically important increase in the anti‐A IgM antibody titers nor a significant correlation between the anti‐A IgM antibody level and anti‐SARS‐CoV‐2S1 antibody titer in the donors with an asymptomatic or mild COVID‐19. Further population‐based studies on anti‐A titers are necessary for a comprehensive assessment of this phenomenon. |
| Databáze: | OpenAIRE |
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