Effect of Sunlight Exposure on Circulating 1,25-Dihydroxyvitamin D in Hemodialyzed Patients and of Exogenous Parathyroid Hormone in Anephric Patients
| Autor: | O H, Sørensen, B, Lund, J D, Thode, T L, Storm, M, Brahm, M, Friedberg, S N, Holmegaard |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Resuscitation 24 25-Dihydroxyvitamin D 3 medicine.medical_treatment Parathyroid hormone Nephrectomy Mixed Function Oxygenases Renal Dialysis Internal medicine Internal Medicine Humans Medicine In patient Calcium metabolism Sunlight Hydroxycholecalciferols business.industry Middle Aged Liver Insufficiency Endocrinology Parathyroid Hormone Injections Intravenous Dihydroxycholecalciferols Female Kidney Diseases Hemodialysis business |
| Zdroj: | Acta Medica Scandinavica. 219:215-219 |
| ISSN: | 0001-6101 |
| DOI: | 10.1111/j.0954-6820.1986.tb03301.x |
| Popis: | Sunshine exposure increased the serum concentration of 25-hydroxyvitamin D (25-OHD) in 9 hemodialyzed patients. Mean 1,25-dihydroxyvitamin D (1,25-(OH)2D) was unchanged, but in two patients with low initial 25-OHD values this increase was accompanied by a rise in circulating 1,25-(OH)2D, although not to normal levels. One hemodialyzed patient developed liver insufficiency with a resultant reduction of serum 25-OHD concentration accompanied by a decrease in serum 1,25-(OH)2D concentration. The results indicate that the circulating levels of 1,25-(OH)2D in patients with end-stage renal failure are to some extent regulated by the serum 25-OHD concentrations. Injection of parathyroid hormone (PTH) induced minor increases in serum concentrations of 1,25-(OH)2D in patients with end-stage renal failure and even in anephric patients, suggesting the existence of an extrarenal PTH-sensitive 1-alpha-hydroxylase. However, the enzyme was stimulated by supraphysiological concentrations of PTH, and therefore not necessarily of importance in the normal regulation of calcium metabolism. |
| Databáze: | OpenAIRE |
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