Total Synthesis of Resiniferatoxin
| Autor: | Vasil H. Vasilev, Lukas Spessert, Kuan Yu, Thomas J. Maimone |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Journal of the American Chemical Society. 144:16332-16337 |
| ISSN: | 1520-5126 0002-7863 |
| Popis: | From both structural and functional perspectives, the large family of daphnane diterpene orthoesters (DDOs) represent a truly remarkable class of natural products. As potent lead compounds for the treatment of pain, neurodegeneration, HIV/AIDS, and cancer, their medicinal potential continues to be heavily investigated, yet synthetic routes to DDO natural products remain rare. Herein we report a distinct approach to this class of complex diterpenes, highlighted by a 15-step total synthesis of the flagship DDO, resiniferatoxin. |
| Databáze: | OpenAIRE |
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